Overview

This is an up-to-date overview on all biochemical and pharmacological aspects of the role of phospholipids in signal transmission. The main topics are the molecular composition of plasma membranes, receptor modeulated effects of phosphoinositide breakdown, metabolism, pharmacology, and clinical effects of natural phospholipids, modulation of signals produced by phospholipid catabolites such as diacylglycerol and phosphatidic acid, and interactions among phospholipids and calcium in neuromodulation. The book is a source of information for all pharmacologists, biochemists, and neuroscientists investigating lipid metabolism and the mechanisms of receptor activation.

Full Product Details

Author:   Raphael Massarelli ,  L. A. Horrocks ,  J. N. Kanfer ,  Konrad Loffelholz
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v. 70
Weight:   0.830kg
ISBN:  

9783540546108

ISBN 10:   3540546103
Pages:   464
Publication Date:   27 May 1993
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Glycosylphosphatidylinositol Anchored Recognition Molecules That Mediate Intercellular Adhesion and Promote Neurite Outgrowth.- Lipid Synthesis and Targeting to the Mammalian Cell Surface.- The Aminophospholipid Transporter from Human Red Blood Cells.- Lipids (Composition and Topography) in Adrenal Chromaffin Granules and Their Relevance for the Function of These Organelles.- Accelerated Cell Membrane Degradation in Alzheimer's Disease Brain: Relationship to Amyloid Formation?.- Mechanistic and Functional Aspects of Oscillatory Calcium Signalling.- Phospholipid Hydrolysis and [Ca2+]i Control.- Phosphoinositide Hydrolysis Indicates Functional Receptors in Astrocytes and in Neoplastic Cells from the Human CNS.- The G-Proteins Regulating Phosphoinositide Breakdown.- Actions and Interactions of Cholinergic and Excitatory Aminoacid Receptors on Phosphoinositide Signals, Excitotoxicity and Neuroplasticity.- The Phospholipid Environment of Activated Synaptic Membrane Receptors May Provide Both Intracellularly and Retrogradely Acting Signals for the Regulation of Neuro(Muscular) Transmission.- The Role of Arachidonic Acid as a Retrograde Messenger in Long-Term Potentiation.- Resisting Memory Storage: Activating Endogenous Protein Kinease C Inhibitors.- B-50 Phosphorylation in Response to Different Patterns of Electrical Stimulation in Rat Hippocampal Slices.- Participation of Inositol Phosphates, Protein Kinase C, G-Proteins and Cyclic AMP in Signal Transduction in Primary Rat Astroglial Cultures.- Sphingosine, a Breakdown Product of Cellular Sphingolipids, in Cellular Proliferation and Phospholipid Metabolism.- Regulation of Phosphatidylserine Synthesis during T Cell Activation.- Anti-Phosphatidylserine Monoclonal Antibody: Structural Template for Studying Lipid-Protein Interactions and for Identification of Phosphatidylserine Binding Proteins.- Immunomodulation by Serine Phospholipids.- Direct Effect of Phosphatidylserine on the Activity of the Post-Synaptic GABAA Receptor Complex.- Phosphatidylserine Reverses the Age-Dependent Decrease in Cortical Acetylcholine Release in the Rat.- Control of Phosphatidylcholine Metabolism.- The Conversion of Ethanolamine Containing Compounds to Choline Derivatives and Acetylcholine.- Phospholipid Metabolism in a Human Cholinergic Cell Line - Possible Involvement of the Base Exchange Enzyme Activities.- Disposition of Choline for the Brain.- The Homeostasis of Brain Choline.- Tacrine (Tetrahydroaminoacridine) and the Metabolism of Acetylcholine and Choline.- CDPcholine, CDPethanolamine, Lipid Metabolism and Disorders of the Central Nervous System.- Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (Platelet Activating Factor) in Cultured Neuronal and Glial Cells.- PAF and Hypothalamic Secretions in the Rat.- Activation of Phospholipid Hydrolysis and Generation of Eicosanoids in Cultured Rat Astroglial Cells by PAF, and Modulation by N-3 Fatty Acids.- A Neural Primary Genomic Response to the Lipid Mediator Platelet-Activating Factor.

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