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OverviewPhosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization. Full Product DetailsAuthor: Tamas Balla , Matthias Wymann , John D. YorkPublisher: Springer Imprint: Springer Edition: 2012 ed. Volume: 59 Dimensions: Width: 15.50cm , Height: 3.00cm , Length: 23.50cm Weight: 0.896kg ISBN: 9789400730144ISBN 10: 9400730144 Pages: 460 Publication Date: 01 March 2012 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1. Ca2+ signalling by IP3 receptors 2. Phosphoinositide signaling during membrane transport in Saccharomyces cerevisiae 3. Phosphoinositides in the mammalian endo-lysosomal network 4. Role of PtdIns(4,5)P2 in vesicle exocytosis and membrane fusion 5. Role of phosphoinositides at the neuronal synapse 6. Phosphatidylinositol 4,5-bisphosphate and the actin cytoskeleton 7. Phosphoinositides in chemotaxis 8. Phosphoinositides in Golgi complex function 9. Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality 10. Phosphoinositide sensitivity of ion channels, a functional perspective 11. Nuclear phosphoinositides: location, regulation and function 12. Phosphoinositides and cellular pathogens 13. Defining signal transduction by inositol phosphates 14. Cell signalling by inositol pyrophosphatesReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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