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OverviewPhosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field. Full Product DetailsAuthor: Tamas Balla , Matthias Wymann , John D. YorkPublisher: Springer Imprint: Springer Edition: 2012 ed. Volume: 58 Dimensions: Width: 15.50cm , Height: 2.50cm , Length: 23.50cm Weight: 0.724kg ISBN: 9789400730113ISBN 10: 940073011 Pages: 356 Publication Date: 14 March 2012 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1. The Phosphatidylinositol 4-kinases: Don’t Call it a Comeback.- 2. PIP kinases from the cell membrane to the nucleus.- 3. The Phospholipase C Isozymes and Their Regulation.- 4. Phosphoinositide 3-Kinases – A Historical Perspective.- 5. PI 3-kinases – drug targets in inflammation and cancer.- 6. Phosphoinositide 3-kinases in health and disease.- 7. Phosphoinositide phosphatases: just as important as the kinases.- 8. The PTEN and myobubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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