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Author:   Riki Kurokawa
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
ISBN:  

9789819948888

ISBN 10:   9819948886
Pages:   318
Publication Date:   03 October 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Chapter 1. FUS aggregation by shear stress on pipetting and its suppression by non-coding RNA.- Chapter 2. Basics and recent advances in computational and theoretical methods for understanding the liquid-liquid phase separation.- Chapter 3.Promotion of liquid-liquid phase separation by G-quadruplex DNA and RNA.- Chapter 4. Phase regulation by chaperons.- Chapter 5. Regulation of aggregation of intrinsically disordered protein through phase separation: Risk management of phase separation.- Chapter 6. Molecular mechanisms of phase transition/separation of protein low-complexity sequences.- Chapter 7. Winding and Tangling. An Initial Phase of Membrane-less Organelle Formation (from a viewpoint of Cajal Bodies).- Chapter 8. Formation and function of phase separated nuclear bodies directed by architectural noncoding RNA.- Chapter 9. Force-dependent remodeling of cell-to-cell adhesion through the regulation of phase separation.- Chapter 10. Neuronal RNA granules: Phase separation, dynamics, and higher brain functions.- Chapter 11. Liquid-liquid phase separation in structure and function of nuclear pore complex.- Chapter 12. Phase Separation Orchestrates Cancer Signaling: Biomolecular condensates as a promising target for cancer therapy.- Chapter 13. Regulatory interaction of intrinsically disordered regions of pathogenic proteins in neurodegenerative diseases.- Chapter 14. Functional properties of phase separation and intranuclear complex of FUS in the pathogenesis of ALS/FTLD.- Chapter 15. Functional responses of microglia to amyloid plaques.- Chapter 16. Emerging role of phage separation in COVID-19.

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Author Information

Riki Kurokawa is a Professor in the Division of Biomedical Sciences at the School of Medicine, Saitama Medical University. He served as a Professor and Chief of the Division of Gene Structure and Function at the Research Center for Genomic Medicine, Saitama Medical University, from 2004 to 2020. His research focuses on gene structure and function, with a particular emphasis on genomic medicineand transcriptional regulation. He has received recognition for his work, including The Award of The Japanese Association for Oral Biology in 1990 and The Nichols Institute New Investigator Award from The Endocrine Society in 1993. 

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