Overview

Hyperlipidaemia is a condition in which blood plasma contains high levels of lipids and/or lipoproteins. This can be primary due to genetic factors or secondary which may be due to underlying things such as diabetes, hypothyroidism, nephrotic syndrome, and alcohol, as well as the dietary intake. Lipids such as cholesterol and triglycerides are insoluble in plasma. Circulating lipid is carried in lipoproteins that transport the lipid to various tissues for energy use, lipid deposition, steroid hormone production, and bile acid formation. Most people who have Hyperlipidaemia experience no symptoms. Abnormalities in lipoprotein metabolism are a major predisposing factor to atherosclerosis, increasing risk for Coronary heart disease (CHD). Cardiovascular disease due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of pre-mature mortality and of disability-adjusted life years, and is also increasingly common in developing countries. The main clinical entities are coronary artery disease, ischaemic stroke, and peripheral arterial disease.

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