Overview

Pulmonary embolism (PE) and deep vein thrombosis (DVT) are collectively known as venous thromboembolism (VTE). VTE affects an estimated 900,000 Americans every year, resulting in significant morbidity and mortality. Although the average annual incidence of DVT currently ranges from 48 to 122 per 100,000 in the United States, rates will rise with the aging population. There are significant adverse consequences of DVT and PE, including an estimated 300,000 fatalities annually and hundreds of thousands of hospitalizations in nonfatal cases. In addition, a diagnosis of DVT or of PE in the hospital increases the costs of the hospitalization by roughly $10,000 and $20,000, respectively. Thus, VTE is an important patient safety issue with significant morbidity, mortality, and health care costs. Accordingly, the comparative effectiveness and safety of interventions for the prevention and treatment of VTE are among the national priorities for comparative effectiveness research. In this review, we describe the evidence about prevention of DVT in

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9781491081112

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