Overview

Drugs are administered to patients with the intention of achieving an expected therapeutic response. Yet drug therapy remains a medical art because of the wide variation in individual responses to standard drug doses. Pharmacogenetics emerged as a field aimed at identifying heritable factors that are predictive of individual variations in drug efficacy and toxicity from the dedicated work of a small group of investigators who in the 1950s began to enrich the discipline of pharmacology by integrating it with human genetics. Pharmacogenetics provides the experimental framework to understand variation in human reactions to drugs and other exogenous substances as a function of inborn human genetic variability. Recently, pharmacogenetics has experienced a period of rapid growth and redefinition. The human genome initiative has provided a wealth of primary genetic information and functional genomic data to fuel the understanding of genetic polymorphism and its functional consequences on a genomic scale. Today, the field of pharmacogenetics is a well-integrated, worldwide network engaging a vast community of academic, institutional, and industrial scientists. The second edition of this highly regarded book provides a systematic and comprehensive account of the foundations, fundamentals, and futures of the field of pharmacogenetics and serves as introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. Dr. Wendell Weber has completely revised and updated each chapter in this new edition to reflect the enormous changes in this field.

Full Product Details

Author:   Wendell Weber (Emeritus Professor, Emeritus Professor, Department of Pharmacology, University of Michigan Medical School, USA)
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Edition:   2nd Revised edition
Dimensions:   Width: 23.90cm , Height: 3.10cm , Length: 16.00cm
Weight:   0.746kg
ISBN:  

9780195341515

ISBN 10:   0195341511
Pages:   448
Publication Date:   10 April 2008
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
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Table of Contents

1: Beginnings Cellular Foundations of Early Pharmacology and Genetics Molecular Foundations of Early Pharmacology and Genetics The Emergence of Modern Genetics and Experimental Pharmacogenetics The Genomics Era The Effect of Molecular Biology on Pharmacogenetics 2: Defining Pharmacogenetics The Genetic Profile of Human Drug Response Evidence for Individual Variation in Drug Response Evidence that Individual Variation is Inherited Interaction with Other Fields Empowers Pharmacogenetics Pharmacogenetics is Park of Ecogenetics Strategies for Gene Identification The Outlook for Pharmacogenetics Summary Fundamentals 3: Pharmacology of Human Drug Response Pharmacology and Genetics of Human Drug Response are Complementary Pharmacogenetics Dose Response Relationships Pharmacokinetics in Pharmacogenetics Pharmacogenetic Mechanisms of Human Drug Response Testing Pharmacogenetic Hypotheses Summary 4: Age-related Pharmacology Age-related Physiologic Variation Pharmacokinetic Variation Pharmacodynamic Variation Summary 5: Genetics in Pharmacology More about Genetic Profiling Drug Response Twin Studies Family Studies Mathematical Treatment of Heterogeneity in Drug Response Impediments to Pharmacogenetic Investigation Summary 6: Epigenetics The Emergence of Epigenetics The Foundations of Epigenetics The Effect of Molecular Biology on Epigenetics Epigenetics in Health and Disease Therapeutic Potential for Epigenetic Disease Summary 7: Genomic Tools Charting the Evolution of Genomic Tools Analytical Techniques Conventional Analysis of Genetic Variants Advances in Genomic Technology Emerging Technologies Summary 8: Ethnic Pharmacogenetics Marrying Race and Ethnicity to Genetic Variation Ethnic Specificity in Drug Response Frequency of Pharmacogenetic Ethnic Specificities Ethnicity as a Starting Point for Pharmacogenetics Ethnicity in Drug Development Ethnic Research and Culturally Specific Risks Summary 9: Modeling Human Drug Response Mouse Models of Pharmacogenetic Traits Constructing Inbred Mouse Models Gene Targeting Creating Mouse Models by Gene Targeting Quantitative Trait Locus Analysis Simple Eukaryotic Organisms as Experimental Models Summary

Reviews

<br>. ..an introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. It is also a very useful collection of material for professors of pharmacology to use in preparing for lectures for every level of student... Compared to other pharmacogenetic textbooks, this one is unique in its inclusion of a chapter on epigenetics. --Doody's<br>

.. .an introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. It is also a very useful collection of material for professors of pharmacology to use in preparing for lectures for every level of student... Compared to other pharmacogenetic textbooks, this one is unique in its inclusion of a chapter on epigenetics. --Doody's Dr. Wendell Weber provides a significant update to his first edition, which appeared in 1997...This book serves as an excellent introduction to the field and includes enough detail to serve as a helpful reference as well...This book provides an initial step in the right direction toward better understanding of this complex and expanding field. -- Jacob William Shatzer, MDiv, Bioethics Press Ltd

.,. an introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. It is also a very useful collection of material for professors of pharmacology to use in preparing for lectures for every level of student... Compared to other pharmacogenetic textbooks, this one is unique in its inclusion of a chapter on epigenetics. --Doody's<br>

. ..an introduction to all facets of pharmacogenetics for physicians, pharmacists, epidemiologists and other professionals in the life sciences. It is also a very useful collection of material for professors of pharmacology to use in preparing for lectures for every level of student... Compared to other pharmacogenetic textbooks, this one is unique in its inclusion of a chapter on epigenetics. --Doody's Dr. Wendell Weber provides a significant update to his first edition, which appeared in 1997...This book serves as an excellent introduction to the field and includes enough detail to serve as a helpful reference as well...This book provides an initial step in the right direction toward better understanding of this complex and expanding field. -- Jacob William Shatzer, MDiv, Bioethics Press Ltd

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