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Author:   Rashid Ali (Jamia Millia Islamia New Delhi, India) ,  Shahid Ul Islam (Indian Institute of Technology Delhi, India)
Publisher:   John Wiley & Sons Inc
Imprint:   Wiley-Scrivener
Weight:   0.671kg
ISBN:  

9781394166541

ISBN 10:   1394166540
Pages:   288
Publication Date:   28 September 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Preface xi 1 Introduction to Ivermectin 1 Aeyaz Ahmad Bhat, Atif Khurshid Wani, Tahir ul Gani Mir and Nahid Akther 1.1 Introduction 1 1.2 Sources and Synthesis 3 1.3 Pharmacological Potential of Ivermectin 4 1.4 Ivermectin's Beneficial Role in Cattle 8 1.5 Ivermectin in the Treatment of COVID-19 8 1.6 Toxicity of Ivermectin 10 1.7 Conclusion 13 2 Historical Background of and Synthetic Approaches to Ivermectin (IVM) and its Homologues 23 Shakeel Alvi, Mohd Kamil Hussain and Rashid Ali 2.1 Introduction 24 2.2 Synthetic Approaches Towards the Construction of IVM and Analogues 29 2.3 Biosynthesis 29 2.4 Chemical Synthetic Pathway 33 2.5 Crystal Structure 42 2.6 Conclusion and Outlook 42 3 Ivermectin as a Repurposed Drug for COVID-19 47 Hari Madhav, Mohammad Rehan, Nasimul Hoda and Ehtesham Jameel 3.1 Introduction 47 3.2 Symptoms of COVID-19 50 3.3 Repurposing of the Drugs 52 3.4 Repurposed Drugs for COVID-19 52 3.5 Repurposing of Ivermectin for COVID-19 53 3.6 Proposed Possible Mechanism of Action 54 3.7 SARS COVID-19 Clinical Studies with Ivermectin 55 3.8 Conclusions 59 3.9 Acknowledgments 60 4 Ivermectin as an Anti-Parasitic Agent 69 Areeba Rahman, Abdulaziz S. Alouffi, Mohammad Husain and Abdur Rub 4.1 Introduction 70 4.2 Use of Ivermectin Against Various Human Parasitic Infections 76 4.3 Mode of Action Against Various Parasites 83 4.4 Conclusions 83 4.5 Acknowledgements 84 5 Emerging Paradigm of Ivermectin and its Hybrids in Elimination of Malaria 93 Iram Irfan, Diksha Shahi, Mukesh C. Joshi, Shailja Singh and Mohammad Abid 5.1 Introduction 94 5.2 Malaria 95 5.3 Life Cycle of Malaria 100 5.4 Drug Against Hepatic Malarial Stage 105 5.5 About Ivermectin 106 5.6 Designing and Synthesis of Ivermectin Inhibitors 107 5.7 Conclusions 112 5.8 Acknowledgments 113 6 Ivermectin: A Potential Repurposed Anti-Cancer Therapeutic 121 Mohd Kamil Hussain, Rashid Ali, Shakir Ahamad, Mohammad Faheem Khan and Mohammad Saquib 6.1 Introduction 122 6.2 Mechanism of Anti-Carcinogenesis 124 6.3 Activation of Chloride Ion Channels 125 6.4 Anti-Mitotic Effect and Inhibition of Angiogenesis 127 6.5 Inhibition of Mitochondrial Respiration 127 6.6 Inhibitor of Cancer Stem Cells (CSCs) 128 6.7 Induction of Immunogenic Cell Death (ICD) 128 6.8 Epigenetic Modulator 129 6.9 Induction PAK1-Mediated Cytostatic Autophagy 129 6.10 Inhibition of P-glycoprotein (P-gp) 130 6.11 Inhibition of Yes-Associated Protein 1 (YAP1) 130 6.12 Inhibition of RNA Helicase 131 6.13 Caspase-Dependent Apoptosis 132 6.14 Activation of Transcription Factor E3 (TFE3) 132 6.15 Inhibition of Wnt-TCF Pathway Responses 132 6.16 Conclusions 133 7 Ivermectin as an Anti-Inflammatory Agent 141 Mudasir Nabi Peerzada and Saurabh Verma 7.1 Introduction 141 7.2 Ant-Inflammatory Action of Ivermectin 147 7.3 Conclusions 155 8 Ivermectin: An Anthelminthic and Insecticide 163 Manisha Arora Pandit and Tarkeshwar 8.1 Introduction 164 8.2 Ivermectin as an Anthelmintic 165 8.3 Insecticidal Activity of Ivermectin 176 9 Potential Applications of Ivermectin (IVM) in Dermatology 199 Vikrant Jayant and Rashid Ali 9.1 Introduction 200 9.2 Mechanism of Action, Toxicity, and Side Effects of IVM 203 9.3 Motivational Approach of IVM in the Treatment of Skin 206 9.4 Role of IVM with Good Anti-Parasitic Properties Against the Infection of Skin 212 9.5 Importance of IVM as an Anti-Cancer or Anti-Tumor Agent in Curing the Skin 219 9.6 Social Value of IVM in the Medical Care of Red Scrotum Syndrome (RSS) 220 9.7 Utility of IVM as an Anti-Inflammatory Drug in the Treatment of Skin-Related Issues 221 9.8 Conclusions 224 10 Antiviral Uses of Ivermectin 231 Shabnam Kawoosa, Rabiah Bashir, Sheeba Nazir, Zubaid-ul-Khazir Rather, Gulam Nabi Yatoo and Nisar Ahmad Khan 10.1 Introduction 231 10.2 Mechanism of Action of Ivermectin 233 10.3 Anti-Viral Effects Against Various DNA and RNA Viruses 236 10.4 Conclusion 242 11 Toxicology, Safety, and Environmental Aspects of Ivermectin 247 Ayesha Akhtar, Nasreen A. Mazumdar and Afreen Inam 11.1 Introduction 247 11.2 Ivermectin’s Antiparasitic Activity 249 11.3 Pharmacology 250 11.4 Adverse Effects in Humans and Animals 251 11.5 Ivermectin and Ectoparasites 255 11.6 Environmental Impact and Biodegradation of Ivermectin 258 11.7 Conclusion 259 References 259 Index 265

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Author Information

Rashid Ali, PhD, is an assistant professor in the Department of Chemistry, Jamia Millia Islamia, New Delhi, India after receiving his PhD from the Indian Institute of Technology Bombay in organic and supramolecular chemistry. He has more than 50 research articles in international journals as well as multiple book chapters. Shahid-ul-Islam, PhD, is a Research Scientist at the Department of Textile & Fiber Engineering, Indian Institute of Technology Delhi (IIT). His areas of interest are antimicrobial coatings, green chemistry, fibers & polymers, polymeric composites and nanocomoposites, and nano-biotechnology. He has published numerous peer-reviewed research articles in journals of high repute as well as contributions to several books published by the Wiley-Scrivener imprint.

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