Pharmaceutical Extrusion Technology

Author:   Isaac Ghebre-Sellassie (MEGA Pharmaceuticals, Morris Plains, New Jersey, USA) ,  Charles E. Martin ,  Feng Zhang ,  James DiNunzio
Publisher:   Taylor & Francis Ltd
Edition:   2nd edition
ISBN:  

9780367735081


Pages:   413
Publication Date:   18 December 2020
Format:   Paperback
Availability:   In Print   Availability explained
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Pharmaceutical Extrusion Technology


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Author:   Isaac Ghebre-Sellassie (MEGA Pharmaceuticals, Morris Plains, New Jersey, USA) ,  Charles E. Martin ,  Feng Zhang ,  James DiNunzio
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Edition:   2nd edition
Weight:   0.453kg
ISBN:  

9780367735081


ISBN 10:   0367735083
Pages:   413
Publication Date:   18 December 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Chapter 1: Twin Screw Extruders for Pharmaceutical Products from a Technical and Historical Perspective. Chapter 2: Extruder Design. Chapter 3: Control Strategy Considerations for Continuous Manufacturing using Hot Melt Extrusion. Chapter 4: Twin Screw Extrusion & Screw Design. Chapter 5: Die Design. Chapter 6: Feeding Technology and Material Handling for Pharmaceutical Extrusion. Chapter 7: Rheology, Torque and Oscillatory Rheometers. Chapter 8: Foam Extrusion. Chapter 9: Melt Pelletization and Size Reduction. Chapter 10: Extended Release Dosage Forms. Chapter 11: Shape Extrusion – Extruded Implantable Drug Delivery Devices: Materials, Applications and Processing. Chapter 12: Film, Sheet and Laminates. Chapter 13: Melt Extruded Amorphous Solid Dispersions. Chapter 14: Process Modeling and Simulation of Extrusion Operations. Chapter 15: Devolatilization via Twin Screw Extrusion: Theory, Tips, and Test Results. Chapter 16: Continuous Granulation Methodologies. Chapter 17: Installation, Commissioning & Qualification. Chapter 18: Extruder Control Systems.

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Author Information

Isaac Ghebre-Sellassie is President, Pharmaceutical Technology Solutions, Morris Plains, New Jersey, and Executive Director and Chief Scientific Officer, MEGA Pharmaceuticals, Asmara, Eritrea. Dr. Ghebre-Sellassie is the author or coauthor of more than 50 professional publications, including Multiparticulate Oral Drug Delivery and Pharmaceutical Pelletization Technology (both titles, Marcel Dekker Inc.), and the holder of 17 patents. A member of the American Association of Pharmaceutical Scientists and the International Society for Pharmaceutical Engineering, he received his M.S. (1978) and Ph.D. (1981) degrees from Purdue University, West Lafayette, Indiana. Charles Martin is President/General Manager of Leistritz Extrusion. He is responsible for the management of a company that provides manufacturing equipment and engineering services to the plastics, medical and pharmaceutical industries in the USA and around the world. Extensively published in trade publications, textbooks and journals, Charlie has delivered 100+ technical presentations at wide-ranging international events, and was the co-editor of the 1st edition of the textbook Pharmaceutical Extrusion Technology. He has been awarded 2 extrusion-related patents. Charlie earned his undergraduate degree from Gettysburg College, Gettysburg, Pennsylvania and MBA from Rutgers University, New Brunswick, New Jersey. Feng Zhang is an assistant professor at the University of Texas at Austin. Dr. Zhang is the author and coauthor of more than 40 publications and more than 10 patents. A member of American Association of Pharmaceutical Scientist, he received his Ph.D. degree (1999) in Pharmaceutical Science from the University of Texas at Austin, Austin, Texas. James DiNunzio is a Principal Scientist in the Formulation Sciences Group at Merck & Co., Inc. and currently leads the Hot-Melt Extrusion Subject Matter Expert team. He received his Ph.D. from the University of Texas at Austin in Pharmaceutics. He has published numerous research articles, book chapters, and is a co-inventor on multiple patents and patent applications. His current research interests include formulation design for melt extruded systems and the development of continuous manufacturing processes.

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