Overview

This work describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process, including preformulation, formulation, process study and optimization, scale-up, robust processes and formulation development. The authors show how to overcome pharmaceutical, technological and economic constraints on experiment design.

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9780824798604

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Reviews

This is definitely a book on experimental design in the classical style, as Box et al. (1978) indicated. The book has plenty of illustrations. It also has very much use of verbal text compared to most design-of-experiments books. - Technometrics Written in a lucid style, the book covers a myriad aspects of DOE [design of experiments] and optimization....Most of the statistical designs popular in pharmaceutical practice have been discussed quite elaborately listing their relative merits and demerits with distinct emphasis to factorial design....The remarkable highlight of the book is that is covers all the important steps in formulation development ....a diversity of graphic outcomes of DOE optimization has been immaculately presented circum-navigating the mathematicostatical complexities.... ...an excellent addition to library shelves in industry and academia - The Eastern Pharmacist, 2000

""This is definitely a book on experimental design in the classical style, as Box et al. (1978) indicated. The book has plenty of illustrations. It also has very much use of verbal text compared to most design-of-experiments books. ""- Technometrics Written in a lucid style, the book covers a myriad aspects of DOE [design of experiments] and optimization....Most of the statistical designs popular in pharmaceutical practice have been discussed quite elaborately listing their relative merits and demerits with distinct emphasis to factorial design....The remarkable highlight of the book is that is covers all the important steps in formulation development ....a diversity of graphic outcomes of DOE optimization has been immaculately presented circum-navigating the mathematicostatical complexities.... ...an excellent addition to library shelves in industry and academia - The Eastern Pharmacist, 2000

Author Information

Lewis, Gareth A.; Mathieu, Didier; Phan-Tan-Luu, Roger

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