Overview

This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines. Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replacedolder-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death. This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.

Full Product Details

Author:   Giorgio Fedele ,  Clara Maria Ausiello
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2019
Volume:   1183
Weight:   0.454kg
ISBN:  

9783030332518

ISBN 10:   3030332519
Pages:   170
Publication Date:   08 January 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis.- Molecular epidemiology of Bordetella pertussis.- Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.- Functional Programming of Innate Immune Cells in Response to Bordetella pertussis Infection and Vaccination.- Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection.- Human Immune Responses to Pertussis Vaccines.- New Pertussis Vaccines: A Need and a Challenge.- Pertussis: Identification, Prevention and Control.- Pertussis in Low and Medium Income Countries: A Pragmatic Approach.- Clinical Findings and Management of Pertussis.- Pertussis Vaccines and Vaccination Strategies. An Ever-Challenging Health Problem.

Reviews

The audience would most appropriately include individuals interested in microbiology, immunology, vaccinology, infectious disease, or public health. Readers who would benefit most would be at the graduate or professional level. ... it would be a good starting point for a wide variety of learners. (Kari Neemann, Doody's Book Reviews, February 26, 2021)

"""The audience would most appropriately include individuals interested in microbiology, immunology, vaccinology, infectious disease, or public health. Readers who would benefit most would be at the graduate or professional level. ... it would be a good starting point for a wide variety of learners."" (Kari Neemann, Doody's Book Reviews, February 26, 2021)"

Author Information

Dr. Giorgio Fedele Istituto Superiore di Sanità Roma, Italy Email : giorgio.fedele@iss.it   Dr. Clara Maria Ausiello Roma, Italy Email : clara.ausiello@gmail.com

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