Overview

The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.

Full Product Details

Author:   Sherif El-Khamisy
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2017
Volume:   1007
Weight:   0.700kg
ISBN:  

9783319869223

ISBN 10:   3319869221
Pages:   260
Publication Date:   18 August 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface - Personalised Medicine: Lessons from Neurodegenration to Cancer, Sherif F. El-Khamisy.- chap. 1 Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair, Dean T. Williams et al.- chap. 2 Nucleotide excision repair: from neurodegeneration to cancer, Liakos et al.- chap. 3 The Role of Protein-Linked DNA Breaks in Personalized Medicine  Walaa R. et al.- chap. 4 The Emerging Role of Proteomics in Precision Medicine: Application in Neurodegenerative Diseases and Neurotrauma, Rana Alaaeddine et al.- chap. 5 The Role of Nitric Oxide from Neurological Disease to Cancer, Ahmed Maher et al.- chap. 6 RNA nuclear export: from neurological disorders to cancer, Guillaume M. Hautbergue.- chap. 7. Can astrocytes be a target for precision medicine, Chloe Allen et al.- chap. 8 Mitochondrial Diseases as Model of Neurodegeneration, Laila A. Selim et al.- chap. 9 Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a ModelOrganism, Arwa A. Abugable et al.- chap. 10 The Power of Zebrafish in Personalised Medicine,  Sarah Baxendale et al.- chap. 11 Alzheimer’s Disease: a Modular Approach Based on GSK-3β Inhibitors Reem k. Arafa et al.- chap. 12. Regenerative medicine: advances from developmental to degenerative diseases, Nicholas F. Blair et al.- chap. 13 Gene therapy in the nervous system: failures and successes, Jayanth S. Chandran et al.- index.

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