Overview

This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level. 

Full Product Details

Author:   Kim Lewis
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2019
Weight:   0.474kg
ISBN:  

9783030252434

ISBN 10:   3030252434
Pages:   295
Publication Date:   26 November 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1:  Evolution under antibiotic treatments: interplay between antibiotic persistence, tolerance and resistance Nathalie Q. Balaban and Jiafeng Liu Chapter 2: Antibiotic persisters and relapsing Salmonella enterica infectionsPeter W. S. Hill and Sophie Helaine Chapter 3: The Biology of Persister Cells in E. coliAlexander Harms Chapter 4: Persister Formation and Antibiotic Tolerance of Chronic InfectionsKim Lewis and Sylvie Manuse Chapter 5: Persister formation driven by TisB-dependent membrane depolarizationBork A. Berghoff and E. Gerhart H. Wagner Chapter 6: Toxin-antitoxin systems and persistenceNathan Fraikin, Frédéric Goormaghtigh and Laurence Van Melderen  Chapter 7: Nutrient depletion and bacterial persistence. Wendy W. K. Mok  and Mark P. Brynildsen Chapter 8: Genetic determinants of persistence in Escherichia coliDorien Wilmaerts, Pauline Herpels, Jan Michiels, Natalie Verstraeten Chapter 9: Persister resuscitationArvi Jõers, Marta Putrinš, Niilo Kaldalu, Hannes Luidalepp, Tanel Tenson Chapter 10: Host-pathogen interactions influencing Mycobacterium tuberculosis persistence and drug tolerance Huiqing Zheng and Robert B. Abramovitch Chapter 11: Drug susceptibility of individual mycobacterial cellsMaikel Boot & Hesper Rego Chapter 12: Antimicrobial drug discovery against persistersWooseong Kim, Iliana Escobar, Beth Burgwyn Fuchs, and Eleftherios Mylonakis

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Professor Kim Lewis, Northeastern University Boston, Massachusetts, USA

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