Overview

There is currently interest in the effect of peroxisome proliferation, and in proliferators and their modes of action. Peroxisomes (or ""microbodies"") are single membrane-limited cytoplasmic organelles present in the cells of animals, plants, fungi and protozoa. This book describes the basic structure and functions of these organelles which are responsible for many cellular functions including an active auxilliary fatty acid B-oxidation system. During treatment with severally clinically used drugs and environmental contaminants, the synthesis of peroxisomes is greatly increased, this proliferation having a number of toxicological consequences particularly in relation to liver cancer.

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