Overview

Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial and regulatory areas of pharmacology and toxicology. This work brings together for the first time researchers who deal specifically with drug-metabolizing enzymes and peroxisome proliferators. It contains an up-to-date review of peroxisome proliferation with detailed tables on the 100 known peroxisome proliferators and studies of their hepatocarcinogenic capacity. Response of cytochrome P450's, UDP glucuronosyltransferases, epoxidehydrolases, glutathione S-transferase, DT-diaphorase and other enzymes are also covered.

Full Product Details

Author:   Mannfred A. Hollinger (University of California, Davis, USA) ,  David E. Moody ,  Bruce D. Hammock (University of California, Davis, California, USA) ,  Richard T. Okita (Washington State University)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   10
Weight:   0.589kg
ISBN:  

9780849383052

ISBN 10:   0849383056
Pages:   200
Publication Date:   12 July 1994
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Peroxisome Proliferation: An Overview, D.E. Moody Induction of Cytochromes P450 by Peroxisome Proliferators, G.G. Gibson, M.J. Diaz, E. Chinje, and P. Kentish Effect of Peroxisome Proliferators on Microsomal P450 Reactions, R.T. Okita Inhibition of Cytochrome P450 4A Enzymes and Peroxisome Proliferation, P. Ortez de Montellano, R.M. Kaikaus, W.K. Chan, Z. Sui, and N.M. Bass Peroxisome Proliferator Activated Receptor-Mediated Induction of P450 4A, E.F. Johnson, M.-H. Hsu, and C.N.A. Palmer UDP-Glucuronosyltransferases and Peroxisome Proliferators, J. Magdalou, S. Fournel-Gigleux, H. Goudonnet, M. Pritchard, and G. Siest The Response of Soluble Epoxide Hydrolase and Other Hydrolytic Enzymes to Peroxisome Proliferators, D.F. Grant, D.E. Moody, J. Beetham, D.H. Storms, M.F. Moghaddam, B. Borhan, F. Pinot, B. Winder, and B.D. Hammock Peroxisome Proliferation and the Subcellular Localization of Soluble Epoxide Hydrolase: Role of Peroxisomal Targeting Sequences, S.S. Gill, D.F. Grant, J.K. Beetham, and C. Chang Responses of Epoxide Hydrolases, Glutathoine S-Transferase, DT-Diaphorase and Catalase in Mouse Liver to Treatment with Peroxisome Proliferators, J.W. DePierre, A.-K. Sohlenius, A.M. Eriksson, M. Soderstrom, H. Permadi, K. Andersson, C. Sundberg, and B. Lundgren Anti-Oxidant Activity Modulation by Peroxisome Proliferators, J.D. Budroe and G.M. Williams Induction of Drug-Metabolizing Enzymes by Short/Intermediate-Term Exposure to Peroxisome Proliferators-A Synopsis, F. Oesch and M. Arand Drug Metabolizing Enzymes as Part of the Unique Phenotypic Properties of Peroxisome Proliferator-Induced Liver Tumors, M.S. Rao and J.K. Reddy).

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