Overview

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from ""bench to bedside,"" beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.

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9780128201411

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Dr. Nir Qvit completed his doctorate in organic chemistry, at the Hebrew University in 2008. His doctorate work focused on developing different strategies for synthesis of small molecules, peptides and peptidomimetics (modified peptides) for various therapeutic applications. Dr. Qvit joined Bar-Ilan University’s team of researchers in the Galilee in October 2017, and is currently the Principle Investigator of the Laboratory for Chemical Biology of Protein-Protein Interactions in the Faculty of Medicine. Dr. Qvit’s current research focuses on development of novel tools to regulate protein-protein interactions. He uses a rational approach to design and develop short peptides and peptidomimetics derived from protein regulatory domains to modulate their function in a selective manner. Dr. Qvit is a reviewer for many scientific journals, including the Journal of Medicinal Chemistry and Journal of Peptide Science; and he was a guest editor of a special issue of Current Topics in Medicinal Chemistry. Dr. “Yoni” Samuel J. S. Rubin completed his PhD in immunology at Stanford University School of Medicine in 2019, followed by postdoctoral training and MD at the same institution. His research focuses on better understanding the molecular and cellular mechanisms underlying chronic immune-mediated diseases and using this knowledge to develop safer, cheaper, and more effective tools for detecting and treating illness worldwide. In the field of mucosal immunology and immune cell trafficking, Dr. Rubin’s findings have inspired the development of novel blood-based methods for detection of gastroenterological conditions. His work has also led to the development of precision medicine therapeutics for the treatment of chronic auto-inflammatory conditions. Dr. Rubin is especially appreciative for the circuitous and often unexpected path that continues to characterize his career. Especially influential were the many instructors and mentors that inspired his dedication to teaching the student and shaped his past and ongoing endeavors. He has served as a guest editor for Current Topics in Medicinal Chemistry and continues to serve as a reviewer for numerous scientific journals. Amongst other awards and recognitions, Dr. Rubin has received the United States National Science Foundation Graduate Research Fellowship and the Hugh McDevitt Prize in Immunology.

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