Overview

A collection of cutting-edge methods for investigating and detecting a wide variety of hematological disorders. Here, the reader will find reliable molecular protocols for the diagnosis of Fanconi anemia and dyskeratosis congenita, immunodeficiency, and most forms of hemoglobinopathy. In addition, there are detailed methods for molecular human platelet antigen genotyping, an effective PCR procedure for thrombophilia screening, and protocols for fluorescent in situ hybridization. Since the measurement of minimal residual disease (MRD) provides a much more accurate risk-directed therapy, three methods are presented for detecting residual leukemia below the threshold of light microscopy, along with relatively simple, rapid, and cheap methods for the detection of MRD in ALL and AML.

Full Product Details

Author:   Nicholas J. Goulden ,  Colin G. Steward
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2004 ed.
Volume:   91
Dimensions:   Width: 15.50cm , Height: 1.70cm , Length: 23.50cm
Weight:   1.280kg
ISBN:  

9781588290434

ISBN 10:   1588290433
Pages:   272
Publication Date:   29 September 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Part I. Bone Marrow Failure Syndromes Molecular Diagnosis of Fanconi Anemia and Dyskeratosis Congenita Alex J. Tipping, Tom J. Vulliamy, Neil V. Morgan, and Inderjeet Dokal Molecular Diagnosis of Diamond-Blackfan Anemia Sarah Ball and Karen Orfali Part II. Red Blood Cell Disorders Antenatal Diagnosis of Hemoglobinopathies John M. Old Part III. Platelet and Hemostatic Disorders Prenatal Diagnosis of Hemophilia David Stirling Human Platelet Antigen Genotyping by PCR-SSP in Neonatal/Fetal Alloimmune Thrombocytopenia Colin Hurd and Geoff Lucas Multiplex PCR for the Detection of the Factor V Leiden and Prothrombin 20210A Mutations Anne M. Sproul and Elizabeth A. Chalmers Part IV. Immunodeficiency Molecular Diagnosis of Congenital Immunodeficiency David Eastwood, Kimberly C. Gilmour, and Hubert B. Gaspar Part V. Acute Leukemia Molecular Techniques to Improve Outcome in Childhood ALL Frederik W. van Delft and Vaskar Saha Molecular Cytogenetics in Childhood Leukemia Christine J. Harrison, Helena Kempski, David W. Hammond, and Lyndal Kearney Fluorescent IgH Fingerprinting to Assess Minimal Residual Disease in Childhood B-Lineage ALL Paul A. S. Evans and Roger G. Owen Real-Time Quantitative RT-PCR to Detect Fusion Gene Transcripts Associated With AML Rajinder Flora and David Grimwade Real-Time PCR to Detect Minimal Residual Disease in Childhood ALL Cornelia Eckert and Olfert Landt Oligonucleotide Microarray Analysis of Gene Expression in Leukemia Frederik W. van Delft and Louise K. Jones Part VI. Bone Marrow Transplantation HLA Low-Resolution Genotyping for Hematopoietic Stem Cell Transplantation John Harvey, Jenny Price, and Ahna Stanton DNA Sequencing as a Tissue-Typing Tool Paul P. J. Dunn, Sarinder Day, Siaron Williams, and Nina Bendukidze Analysis of Chimerism After Stem Cell Transplantation Peter Bader and Hermann Kreyenberg Index

Reviews

Pediatric Hematology, Methods and Protocols, is an excellent reference book for physicians and scientists who serve pediatric patients in the specialty of hematology. This book is a valuable technical manual for laboratory scientists to set up new diagnostic tests and to troubleshoot and improve their current diagnostic methods. It is also a very practical guideline for physicians to choose relevant tests to arrive at correct diagnoses in light of clinical history and symptoms. The book is well organized, concisely written, and easy to understand. To the best of my knowledge, no other book describes the molecular diagnostic methods of pediatric hematologic disorders in such detail. I highly recommend this book for laboratories of hematology and molecular diagnosis in hospitals serving pediatric patients. - Society for Pediatric Pathology

Pediatric Hematology, Methods and Protocols, is an excellent reference book for physicians and scientists who serve pediatric patients in the specialty of hematology. This book is a valuable technical manual for laboratory scientists to set up new diagnostic tests and to troubleshoot and improve their current diagnostic methods. It is also a very practical guideline for physicians to choose relevant tests to arrive at correct diagnoses in light of clinical history and symptoms. The book is well organized, concisely written, and easy to understand. To the best of my knowledge, no other book describes the molecular diagnostic methods of pediatric hematologic disorders in such detail. I highly recommend this book for laboratories of hematology and molecular diagnosis in hospitals serving pediatric patients. -Society for Pediatric Pathology The information in this book is clearly expressed...a useful and practical text for laboratory scientists... - Journal of Pediatrics and Child Health

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