Overview
This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.
Full Product Details
Author: Anton Yuryev , Sean Ekins
Publisher: John Wiley & Sons Inc
Imprint: John Wiley & Sons Inc
Dimensions:
Width: 16.10cm
, Height: 2.20cm
, Length: 24.10cm
Weight: 0.617kg
ISBN: 9780470107058
ISBN 10: 0470107057
Pages: 336
Publication Date: 17 October 2008
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: Out of stock 
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Table of Contents
Preface vii Contributors ix 1 Introduction to Pathway Analysis 1 Anton Yuryev 2 Software Infrastructure and Data Model for Pathway Analysis 27 Fedor Bokov and Anton Yuryev 3 Automatic Pathway Inference in Heterogeneous Biological Association Networks 47 Anton Yuryev, Andrey Kalinin, and Nikolai Daraselia 4 Algorithmic Basis for Pathway Visualization 67 Sergey Simakov, Iaroslav Ispolatov, Sergei Maslov, and Alexander Nikitin 5 Pathway Analysis of High-Throughput Experimental Data 103 Andrey Y. Sivachenko 6 Integrative Pathway Analysis of Disease Molecular Data 121 Andrej Bugrim, Zoltan Dezso, Yuri Nikolsky, and Tatiana Nikolskaya 7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways,Potential Targets, and Noise 149 John Farley, Laurent L. Ozbun, and Michael J. Birrer 8 Mammalian Proteome and Toxicant Network Analysis 165 Sean Ekins and Craig N. Giroux 9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an IllustrativeExample 195 Mark P. Kühnel, Bojana Cosovic, Goran Medic, Robert B. Russell, and Gordana Apic 10 Impact of Chemistry Information on Pathway Analysis 219 Sreenivas Devidas 11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks 237 Sergei Maslov and Iaroslav Ispolatov 12 An Adaptive System Model of the Yeast Glucose Sensor System 263 Todor Vujasinovic and André Siniša ampera 13 Present and Future of Pathway Analysis in Drug Discovery 285 Anton Yuryev Index 297
Reviews
Pathway analysis will help lead to a better understanding of the chemistry of living systems and the aberrations that disrupt health. This new book will serve as a beacon to research interested in this field. ( Journal of Medicinal Chemistry , April 9, 2009)
Pathway analysis will help lead to a better understanding of the chemistry of living systems and the aberrations that disrupt health. This new book will serve as a beacon to research interested in this field. (Journal of Medicinal Chemistry, April 9, 2009)
Author Information
ANTON YURYEV, PhD, is the Senior Director of Application Science at Ariadne Genomics Inc. His department studies the topological and evolutionary properties of biological networks and develops algorithms for pathway reconstruction and analysis of high-throughput data. Dr. Yuryev has published more than thirty scientific publications and is the author of several algorithms for primer design and pathway analysis.
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