Overview

The “Pathophysiology of Cancer: An Interdisciplinary Approach” is the twenty-two volume of the “Interdisciplinary Cancer Research” series and a comprehensive volume on the pathophysiology of cancer. The volume starts with a few chapters on the risk of cancer development and carcinogenesis, including mitochondrial energy metabolism in carcinogenesis and the role of mitochondrial DNA mutations in cancer development. The obesity epidemic and cancer risk, urban road dust, genotoxicity, aberrant glycosylation, melatonin, and matrix metalloproteinases as players in cancer development and progression are explained in other chapters. The subsequent chapters discuss vascular endothelium, extracellular vesicles and extracellular matrix, circulating tumor cells, cancer-associated programmed-cell death, and epithelial-to-mesenchymal transition in cancer. Importance of antioxidants, decoding metabolic changes and effects of secondary metabolites in cancer therapy are the subjects of the concluding chapters. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for those who wish to have an update on the pathophysiology of cancer.

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9783031992261

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Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital.  Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research and Technologies, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the Founder of Universal Scientific Education and Research Network (USERN). Prof. Rezaei has already been the Director of more than two hundred research projects and has designed and participated in several international collaborative projects. Prof. Rezaei is the editor, editorial assistant, or editorial board member of more than fifty international journals. He has edited more than one hundred international books, has presented more than a thousand lectures/posters in congresses/meetings, and has published more than 1,500 scientific papers in the international journals.

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