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Author:   Gabor M. Rubanyi (Berlex Biosciences,Richmond, California, USA)
Publisher:   Taylor & Francis Ltd
Imprint:   Taylor & Francis Ltd
Volume:   v. 5
Dimensions:   Width: 21.00cm , Height: 5.90cm , Length: 28.00cm
Weight:   1.832kg
ISBN:  

9789057024153

ISBN 10:   9057024152
Pages:   660
Publication Date:   23 June 1999
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Unknown
Availability:   Out of stock  

Table of Contents

Part A. Part 1 Generation and biological actions of nitric oxide: nitric oxide synthase gene regulation; localization and subcellular targeting of nitric oxide; molecular mechanisms of peroxynitrite reactivity; nitric oxide and gene transcription; regulation of nitric oxide synthase expression and activity by haemodynamic forces; mice deficient in eNOS and nNOS isoforms. Part 2 Nitric oxide and pathophysiology of diseases: hypertension; atherosclerosis - role of NO; nitric oxide and circulatory shock; kidney disease; the role of nitric oxide in preterm labour; multiple sclerosis; regulation of nitric oxide in human osteoarthritis-affected cartilage; the role of nitric oxide in rheumatoid arthritis; gastrointestinal function in shock. Part 3 Therapeutic applications: nitric oxide inhalation; nitric oxide synthase inhibitors; the pharmacology of peroxynitrite-dependent neurotoxicity blockade; gene therapy approaches with iNOS.

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