Overview

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Full Product Details

Author:   Jean Pieters ,  John D. McKinney
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2013
Volume:   374
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   3.927kg
ISBN:  

9783662521427

ISBN 10:   3662521423
Pages:   245
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

 Genetic Diversity in Mycobacterium tuberculosis Sebastien Gagneux   DNA Metabolism in Mycobacterial Pathogenesis Digby F. Warner, Tone Tønjum and Valerie Mizrahi   Molecular Biology of Drug Resistance in Mycobacterium tuberculosis Tasha Smith, Kerstin A. Wolff, and Liem Nguyen   Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations John D. Szumowski, Kristin N. Adams, Paul H. Edelstein, and Lalita Ramakrishnan   Getting Across the Cell Envelope: Mycobacterial Protein Secretion Aniek D. van der Woude, Joen Luirink, and Wilbert Bitter   A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria Giulia Manina and John D. McKinney   Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes Sabine Ehrt and Kyu Rhee   Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters   Host-Pathogen Interactions During Mycobacterium tuberculosis Infections Sarah Stanley and Jeffery S. Cox  

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