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Author:   John F. Prescott (University of Guelph, Ontario, Canada) ,  Janet I. MacInnes (University of Guelph, Ontario, Canada) ,  Filip Van Immerseel (Ghent University, Merelbeke, Belgium) ,  John D. Boyce (Monash University, Victoria, Australia)
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-Blackwell
Edition:   5th edition
Dimensions:   Width: 18.80cm , Height: 3.80cm , Length: 25.70cm
Weight:   1.792kg
ISBN:  

9781119754794

ISBN 10:   1119754798
Pages:   816
Publication Date:   15 September 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Preface xv List of Contributors xvii About the Companion Website xxv 1 Themes in Bacterial Pathogenesis 1 John F. Prescott Introduction 1 The Basic Elements of Bacterial Pathogenesis 1 Concepts of Bacterial Virulence are Being Refined 5 Host–Pathogen Communications are Critical 9 Pathogenesis in the Post-Genomic Era 11 Gaps in Knowledge and Anticipated Directions 13 References 13 2 Evolution of Bacterial Pathogens 15 Patrick Boerlin What are Pathogens and How Do They Emerge? 15 Bacterial Fitness and Virulence 17 Sources of Genetic Diversity, Population Structure, and Genome Plasticity 18 Pathogenicity Islands 20 Bacteriophages and Their Role in Pathogen Evolution and Virulence 22 Examples of Virulence Evolution 23 Gaps in Knowledge and Anticipated Directions 27 References 28 3 Understanding Pathogenesis Through Pathogenomics and Bioinformatics 32 Gregorio Iraola and John D. Boyce Introduction 32 How Mutations Generate Bacterial Diversity 34 Genome Sequencing Technologies 36 Genome Assembly 38 Gene Prediction and Annotation 39 Defining Prokaryotic Species from Genomes 41 The Pangenome Concept, Reconstruction, and Comparative Analyses 41 Phylogenomics and Genome-Wide Association Studies 42 Functional Genomics for Understanding Host–Pathogen Interactions 44 Reverse Vaccinology 48 Gaps in Knowledge and Anticipated Directions 51 References 52 4 Experimental Approaches to Understanding Pathogenesis 57 Francesca L. Short and Janet I. MacInnes Introduction 57 Testing Koch’s Postulates 57 Virulence Factors and Main Steps in Pathogenesis 58 Molecular Koch’s Postulates 60 Refining Animal Usage 60 Experimental Approaches for Virulence Factor Discovery and Validation 62 Approaches for Virulence Factor Discovery 63 Gene Disruption Approaches for Virulence Factor Discovery 71 Bringing It All Together: Validation and Further Characterization of Virulence Factors 73 Two Stories of Virulence Factor Discovery and Characterization: Pasteurella multocida Capsule, and Mycoplasma bovis Adhesins 74 Gaps in Knowledge and Anticipated Directions 75 References 76 5 Subversion of the Immune Response by Bacterial Pathogens 79 Douglas C. Hodgins, Raveendra R. Kulkarni, and Patricia E. Shewen Introduction 79 Subversion of Innate Responses 80 Subversion of Adaptive Immunity 85 Manipulation of Cell Fate 88 Non-Coding RNA and Host-Pathogen Interactions 91 Epigenetic and Genetic Modulation 92 Gaps in Knowledge and Anticipated Directions 94 References 94 6 Chinks in the Armor 99 Allison C. Leonard, Celine Stoica, and Georgina Cox Introduction 99 Virulence Factors: Pathogenesis-Based Targets to Combat Bacterial Pathogens 99 Targeting Bacterial Host Cell Adhesion and Biofilm Formation 100 Quorum Sensing Inhibition 104 Interfering with Two-Component Regulatory Systems 105 Inhibiting Bacterial Motility 106 Toxin Neutralization 107 Inhibitors of Bacterial Secretion Systems 107 Targeting Nutrient Acquisition: Starving the Pathogen 110 Antivirulence Phage Therapy 111 Bacterial Drug Efflux Pumps as Pathogenesis-Based Antibacterial Targets 112 Gaps in Knowledge and Anticipated Directions 112 References 113 7 Escherichia coli 117 John M. Fairbrother and Carlton L. Gyles Introduction 117 Pathotypes of E. coli and Associated Disease and Pathological Changes in Animals 119 Virulence Factors of Pathogenic E. coli 126 Pathogenesis of Enterotoxigenic E. coli 141 Pathogenesis of Enteropathogenic E. coli Disease 144 Pathogenesis of Shiga Toxin-Producing E. coli Disease 146 Pathogenesis of Extraintestinal Pathogenic E. coli Infections 149 Gaps in Knowledge and Anticipated Directions 156 References 157 8 Salmonella 162 Paul A. Barrow, Michael A. Jones, Kate C. Mellor, and Nick R. Thomson Introduction 162 Characteristics of the Organism 162 Types of Disease and Pathologic Changes 167 Salmonella Infections in Different Major Farmed Animal Species 169 Virulence Factors 174 Pathogenesis 179 Immunity to Infection and its Manipulation by Salmonella 186 Antimicrobial Resistance 190 Gaps in Knowledge and Anticipated Directions 191 References 192 9 Yersinia 200 Anne-Sophie Le Guern and Javier Pizarro-Cerdá Introduction 200 Characteristics of the Organism 200 Pathogenic Species 200 Taxonomy 201 Major Virulence Factors of the Highly Pathogenic Yersinia 203 Yersinia pestis 205 Yersinia pseudotuberculosis and Yersinia enterocolitica 209 Yersinia ruckeri 213 Yersinia entomophaga 213 Control of Yersinia Infections 214 Gaps in Knowledge and Anticipated Directions 214 References 215 10 Pasteurella 221 Marina Harper, Thomas R. Smallman, and John D. Boyce Introduction 221 Characteristics of the Organism 221 Source of Infection: Ecology, Evolution, and Epidemiology 223 Types of Disease and Pathologic Changes 223 Virulence Factors and Pathogenomics 225 Regulation of Virulence 233 Pathogenesis 235 Immunity 236 Control 238 Gaps in Knowledge and Anticipated Directions 239 References 239 11 Mannheimia and Bibersteinia 244 Jeff L. Caswell and Charles J. Czuprynski Introduction 244 Characteristics of the Organism 244 Pathogenic Species 245 Source of Infection: Ecology, Evolution, and Epidemiology 245 Types of Disease and Pathologic Changes 247 Virulence Factors and Pathogenomics 249 Regulation of Virulence 250 Pathogenesis 251 Immunity 254 Control 254 Gaps in Knowledge and Anticipated Directions 255 References 256 12 Actinobacillus 262 Janine T. Bossé, Adina R. Bujold, and Lu Li Introduction 262 Actinobacillus pleuropneumoniae 262 Actinobacillus lignieresii 277 Actinobacillus equuli 278 Actinobacillus suis 279 Gaps in Knowledge and Future Directions 281 References 283 13 Other Pasteurellaceae: Avibacterium, Bibersteinia, Gallibacterium, Glaesserella, and Histophilus 290 Anders M. Bojesen, Virginia Aragon, and Pat J. Blackall Introduction 290 Avibacterium 290 Bibersteinia 292 Gallibacterium 295 Glaesserella parasuis 301 Histophilus 309 References 311 14 Pseudomonas 318 Erin L. Westman, Véronique L. Taylor, and Joseph S. Lam Introduction 318 Characteristics of the Organism 318 Pathogenic Species 319 Sources of Infection: Ecology, Evolution, and Epidemiology 320 Types of Disease and Pathologic Changes 320 Virulence Factors and Pathogenomics 321 Pathogenesis 328 Immunity 330 Control, Prevention, and Treatment 331 Gaps in Knowledge and Anticipated Directions 335 References 337 15 Moraxella 344 John A. Angelos Introduction 344 Infectious Bovine Keratoconjunctivitis 344 Pathogenesis of Moraxella bovis Infection 346 Immunity 352 Control 354 Gaps in Knowledge and Future Directions 354 References 355 16 Brucella 361 Clayton C. Caswell, Angela Arenas-Gamboa, and Jeff T. Foster Introduction 361 Characteristics of the Organism 361 Pathogenic Species 362 Source of Infection: Ecology, Evolution, and Epidemiology 362 Types of Disease and Pathologic Changes 363 Virulence Factors 366 Regulation of Virulence 368 Pathogenomics 369 Pathogenesis 370 Immunity 370 Control 371 Gaps in Knowledge and Anticipated Directions 371 References 372 17 Bordetella 376 Colleen J. Sedney, Tracy L. Nicholson, and Eric T. Harvill Introduction 376 Characteristics of the Organisms 376 Pathogenic Species 377 Source of Infection: Ecology and Epidemiology 379 Types of Disease and Pathologic Changes 380 Virulence Factors 380 Regulation of Virulence 385 Pathogenesis 385 Immunity 385 Control 387 Gaps in Knowledge and Anticipated Directions 389 References 389 18 Campylobacter 393 Zuowei Wu, Orhan Sahin, and Qijing Zhang Introduction 393 Diseases, Etiology, and Ecology 394 Clinical Observations and Pathologic Changes 397 Pathogenesis and Virulence Factors 398 Pathogenomics and Evolution 402 Immunity 405 Control 406 Gaps in Knowledge and Future Directions 407 References 408 19 Helicobacter 413 Chloë De Witte, Helena Berlamont, and Freddy Haesebrouck Introduction 413 Gastric Helicobacters 413 Enterohepatic Helicobacters 425 Gaps in Knowledge and Future Directions 426 References 427 20 Chlamydia and Coxiella 433 Martina Jelocnik, Wilhelmina M. Huston, and Hayley J. Newton Introduction 433 Chlamydiae 433 Characteristics of the Organism 433 Source of Infection: Ecology, Evolution and Epidemiology 436 Types of Disease and Pathologic Changes 436 Pathogenesis 442 Immunity and Control 442 Gaps in Knowledge and Anticipated Directions 443 Coxiella burnetii 443 Characteristics of the Organism 444 Source of Infection: Ecology, Evolution and Epidemiology 445 Types of Disease and Pathologic Changes 445 Virulence Factors and Pathogenomics 447 Immunity and Control 448 Gaps in Knowledge and Anticipated Directions 449 References 449 21 Rickettsiales 456 Jere W. McBride, Roman R. Ganta, and David H. Walker Introduction 456 Family Anaplasmataceae 457 Anaplasma Species 457 Ehrlichia Species 463 Neorickettsia Species 474 Family Rickettsiaceae 476 Rickettsia Species 476 References 480 22 Lawsonia intracellularis 486 Roberto M. C. Guedes, Fabio A. Vannucci, and Connie J. Gebhart Introduction 486 Characteristics of the Organism 486 Sources of Infection: Ecology and Epidemiology 489 Types of Disease and Pathologic Changes 490 Virulence Factors and Pathogenomics 491 Pathogenesis 492 Immunity 496 Control 497 Gaps in Knowledge and Anticipated Directions 497 References 498 23 Leptospira 502 Cyrille Goarant, Ben Adler, and Alejandro de la Peña Moctezuma Introduction 502 Characteristics of the Organism 502 Leptospira Species 505 Source of Infection: Ecology, Evolution, and Epidemiology 505 Clinical Presentation and Signs 511 Virulence Factors and Pathogenomics 511 Regulation of Virulence 514 Pathogenesis 514 Immunity 516 Control 518 Gaps in Knowledge and Anticipated Directions 518 References 519 24 Brachyspira 528 Joseph E. Rubin and Judith Rohde Introduction 528 Characteristics of the Organism 528 Pathogenic Species and Disease Associations 529 Source of Infection: Ecology, Evolution, and Epidemiology 530 Virulence Factors and Pathogenomics 531 Pathogenesis 531 Immunity 537 Control 538 Gaps in Knowledge and Anticipated Directions 538 References 539 25 Staphylococcus 543 Amy C. Pickering, Andreas F. Haag, José R. Penades, and J. Ross Fitzgerald Introduction 543 Characteristics of the Organism 543 Pathogenic Species 544 Staphylococcus aureus Infections in Cattle 546 Staphylococcus aureus Infections in Poultry 551 Staphylococcus aureus Infections in Rabbits 553 Staphylococcus hyicus Infections in Pigs 554 Staphylococcus pseudintermedius Infections in Dogs 556 Gaps in Knowledge and Future Directions 559 References 560 26 Streptococcus 565 John F. Timoney Introduction 565 Characteristics of the Organism 565 Pathogenic Species 565 Streptococcus agalactiae 567 Streptococcus dysgalactiae 569 Streptococcus uberis 570 Streptococcus equi 571 Streptococcus zooepidemicus 577 Streptococcus canis 579 Streptococcus suis 580 Gaps in Knowledge and Anticipated Directions 583 References 583 27 Bacillus anthracis 588 Joachim Frey Introduction 588 Characteristics of the Organism: Taxonomy and Phylogeny 588 Source and Spread of the Infection: Ecology, Evolution, and Epidemiology 591 Types of Disease and Pathologic Changes 592 Virulence Factors and Pathogenomics 594 Regulation of Virulence 595 Pathogenesis 596 Immunity and Vaccines 598 Control and Prevention of Anthrax 598 Gaps in Knowledge and Anticipated Directions 600 References 601 28 Enteric Clostridia 607 Evelien Dierick, Evy Goossens, John F. Prescott, Richard Ducatelle, and Filip Van Immerseel Introduction 607 Clostridium perfringens 607 Characteristics of the Organism 607 Pathogenic Types 608 Sources of Infections: Ecology, Evolution and Epidemiology 608 Types of Disease and Pathologic Changes 611 Virulence Factors 616 Regulation of Virulence 622 The Pathogenesis of Clostridium perfringens Enteric Disease 622 Control 625 Gaps in Knowledge and Anticipated Directions 625 Clostridioides difficile 626 Characteristics of the Organism 626 Source of Infection: Ecology, Evolution and Epidemiology 626 Types of Disease and Pathologic Changes 627 Disease 627 Virulence Factors and Pathogenomics 627 Regulation of Virulence 628 Pathogenesis 629 Immunity 630 Control 630 Gaps in Knowledge and Anticipated Directions 630 Other Enteric Clostridia 630 References 631 29 Histotoxic Clostridia 635 Andrew N. Rycroft Introduction 635 Characteristics of the Organisms 635 Source of Infection and Basic Pathogenesis 636 Pathogenic Species 636 Clostridium septicum (Malignant Edema/Gas Gangrene) 638 Clostridium chauvoei (Blackleg) 639 Paeniclostridium sordellii 640 Clostridium novyi Type B (Black Disease/Bighead) 642 Clostridium haemolyticum 643 Clostridium perfringens 644 Control 645 Gaps in Knowledge and Future Directions 645 References 646 30 Neurotoxic Clostridia 648 Michel R. Popoff Introduction 648 Characteristic of the Organisms 648 Clostridium botulinum 648 Clostridium tetani 650 Sources of Infection: Ecology and Epidemiology 652 Diseases 656 Botulism 656 Tetanus 657 Virulence Factors 658 Pathogenesis 659 Control 663 References 664 31 Mycoplasmas 667 Pollob K. Shil, Nadeeka K. Wawegama, Glenn F. Browning, Amir H. Noormohammadi, and Marc S. Marenda Introduction 667 Characteristics of the Organisms 667 Pathogenic Species 668 Source of Infection: Ecology, Evolution, and Epidemiology 668 Virulence Factors and Pathogenomics 670 Regulation of Virulence 674 Types of Disease and Pathologic Changes 674 Pathogenesis 680 Immunity 688 Control 690 Gaps in Knowledge and Anticipated Directions 690 References 691 32 Corynebacterium, Arcanobacterium, and Trueperella 701 Thiago D. Barral, Ricardo W. Portela, Núbia Seyffert, and Robert J. Moore Corynebacterium 701 Corynebacterium pseudotuberculosis 701 Bovine Pyelonephritis Caused by Corynebacterium Species 706 Other Animal Pathogenic Corynebacterium Species 706 Arcanobacterium 707 Trueperella 709 Gaps in Knowledge and Future Directions 710 References 710 33 Rhodococcus equi 715 José A. Vázquez-Boland, Macarena G. Sanz, and John F. Prescott Introduction 715 Characteristics of the Organism 715 Source of Infection and Epidemiology 717 Types of Disease and Pathologic Changes 720 Virulence Factors 721 Evolution of Rhodococcus equi Virulence 723 Pathogenesis 724 Immunity 726 Treatment and Control 728 Gaps in Knowledge and Anticipated Directions 730 References 731 34 Mycobacterium 736 Karren M. Plain, Karen Stevenson, Richard J. Whittington, and Nathalie Winter Introduction 736 Characteristics of the Organism 736 Sources of Infection 738 Source of Infection: Evolution and Epidemiology 739 Virulence Factors and Pathogenomics 740 Regulation of Virulence 742 Types of Disease 743 Pathogenesis 744 Adaptive Immunity and Mycobacterial Pathogenesis 748 Control 750 Gaps in Knowledge and Anticipated Directions 750 References 752 35 Gram-Negative Anaerobes 757 John F. Prescott Introduction 757 General Bacterial Pathogenesis Aspects 757 Fusobacterium 759 Bacteroides 763 Prevotella and Porphyromonas 764 Dichelobacter nodosus 765 Treponema 767 Gaps in Knowledge and Anticipated Developments 768 References 768 Index 773

Reviews

"""The book is well-produced and a useful update on bacterial pathogenesis from a genomics standpoint. It belongs in the diagnostic laboratory, and not just on the bacteriologist’s shelf."" - Journal of Veterinary Diagnostic Investigation, 2023, Vol. 35(2) 217–218"

The book is well-produced and a useful update on bacterial pathogenesis from a genomics standpoint. It belongs in the diagnostic laboratory, and not just on the bacteriologist's shelf. - Journal of Veterinary Diagnostic Investigation, 2023, Vol. 35(2) 217-218

Author Information

John F. Prescott is University Professor Emeritus at the University of Guelph, in Guelph, Ontario, Canada. Janet I. MacInnes is Professor Emerita at the University of Guelph in Guelph, Ontario, Canada. Filip Van Immerseel is Professor at Ghent University in Merelbeke, Belgium. John D. Boyce is Associate Professor at Monash Biomedicine Discovery Institute, Monash University, in Clayton, Victoria, Australia. Andrew N. Rycroft is Professor at the Royal Veterinary College, in Hatfield, Hertfordshire, United Kingdom. José A. Vázquez-Boland is Professor at the University of Edinburgh in Edinburgh, United Kingdom.

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