Overview

An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, Parkinson’s Disease: Genetics and Pathogenesis spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. The book reviews the major aspects of the disease including motoric and pathologic features, autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations. It also provides an in-depth review of genetic considerations. With contributions by recognized experts on the topic, emphasis is placed on pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field.

Full Product Details

Author:   Ted M. Dawson
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   83
Dimensions:   Width: 15.20cm , Height: 2.30cm , Length: 22.90cm
Weight:   0.635kg
ISBN:  

9780849336973

ISBN 10:   084933697
Pages:   404
Publication Date:   25 April 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

OVERVIEW. Neuropathology and Staging of Parkinson's Disease. Genetics of Parkinson's Disease. Epidemiology of Parkinson's Disease. Treatment of Parkinson's Disease. GENETICS. Genetics of Alpha-Synuclein. Clinical and Genetic Features of PARKIN-Related Parkinson's Disease. DJ-1 in Parkinson's Disease. PINK1 Parkinsonism. LRRK2. Genetics of Tau in Parkinsonism. Genetic Risk Factors for PD. PATHOGENESIS. Alpha-Synuclein and Parkinson's Disease. Tau in Parkinson's Disease. The Role of PARKIN in Parkinson's Disease. Mitochondrial Complex I Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based Pathogenesis. The Ubiquitin-Proteasome System in Parkinson's Disease. ANIMAL MODELS. Transgenic Models of Alpha-Synucleinopathy. Mouse Models of Recessive Parkinsonism. Drosophila Models of Parkinson's Disease. C. Elegans Models of Parkinson's Disease. The MPTP Model of Parkinson's Disease. Rotenone Model. Drug Trials in Animal Models of PD

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Ted M. Dawson

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