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OverviewFrom the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes. Full Product DetailsAuthor: Juan Domínguez-BendalaPublisher: Humana Press Inc. Imprint: Humana Press Inc. Edition: 2009 Dimensions: Width: 15.50cm , Height: 0.90cm , Length: 23.50cm Weight: 0.260kg ISBN: 9781617794865ISBN 10: 1617794864 Pages: 154 Publication Date: 02 December 2011 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of Contents1: Preface. Importance of the subject in the context of type I diabetes. 2: The pancreas. 3: Pancreatic development. 4: Pancreatic regeneration. 1. Models of regeneration. 2. Stem cells vs. beta cell replication. 5: Stem cell differentiation: general approaches. 1. Recapitulation of pancreatic development. 2. Signal-driven strategies. 3. Gene transfer and protein transduction. 4. Physiological variables. 6: Embryonic stem cells and pancreatic differentiation. 7: Adult stem cells and pancreatic differentiation. 1. Bone marrow. 2. Umbilical cord. 3. Ductal and acinar cells. 4. Mesenchymal stem cells and de-differentiation. 8: Transdifferentiation. 9: Remaining challenges and clinical perspectives.ReviewsFrom the reviews: There are 69 instructive pictures showing the schemes of individual processes and 787 selected up to date references. There are very useful several insertion explaining individual special terms by a simple and instructive way. This small and valuable book containing a number of up to date and prospective information ! of great value not only for those who are directly involved in diabetes and related problems, but for all those who like to understand the medicine of the future, including medical students. (Endocrine Regulations, 2009) Part of the series Stem Cell Biology and regenerative Medicine, this book discusses a field of great interest at present. ! With 787 references. For research diabetologists. (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010) From the reviews: There are 69 instructive pictures showing the schemes of individual processes and 787 selected up to date references. There are very useful several insertion explaining individual special terms by a simple and instructive way. This small and valuable book containing a number of up to date and prospective information ... of great value not only for those who are directly involved in diabetes and related problems, but for all those who like to understand the medicine of the future, including medical students. (Endocrine Regulations, 2009) Part of the series Stem Cell Biology and regenerative Medicine, this book discusses a field of great interest at present. ... With 787 references. For research diabetologists. (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010) From the reviews: There are 69 instructive pictures showing the schemes of individual processes and 787 selected up to date references. There are very useful several insertion explaining individual special terms by a simple and instructive way. This small and valuable book containing a number of up to date and prospective information ... of great value not only for those who are directly involved in diabetes and related problems, but for all those who like to understand the medicine of the future, including medical students. (Endocrine Regulations, 2009) Part of the series Stem Cell Biology and regenerative Medicine, this book discusses a field of great interest at present. ... With 787 references. For research diabetologists. (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010) Author InformationTab Content 6Author Website:Countries AvailableAll regions |