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Author:   Susumu Seino ,  Graeme I. Bell
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   Softcover reprint of hardcover 1st ed. 2008
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   0.747kg
ISBN:  

9784431998372

ISBN 10:   4431998373
Pages:   476
Publication Date:   21 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Pancreatic Beta Cell and Insulin Biosynthesis.- Architecture of Pancreatic Islets.- Transcriptional Regulation of Insulin Gene Expression.- The Biosynthesis of Insulin.- Cell Signaling and Insulin Secretion.- Metabolic Regulation of Insulin Secretion.- Mechanisms of Beta-Cell Death in Diabetes.- Ion Channels and Insulin Secretion.- Gap Junctions and Insulin Secretion.- Protein Kinase A-Independent Mechanism of cAMP in Insulin Secretion.- Regulation of Insulin Granule Exocytosis.- Mechanism of Insulin Exocytosis Analyzed by Imaging Techniques.- Two-Photon Excitation Imaging of Insulin Exocytosis.- Pancreatic Development and Beta-Cell Formation.- Regulation of Beta-Cell Growth and Death.- Beta-Cell Replication.- Stem Cells as a Cure for Diabetes.- Use of Extra-Pancreatic Tissues for Cell Replacement Therapy for Diabetes.- Incretins and Beta-Cell Function.- Molecular Biology of Gluco-Incretin Function.- Incretins and Regulation of Insulin Secretion.- Pancreatic Beta Cell and Disease.- Pancreatic Islet Pathology in Type 2 Diabetes.- Genetic Disorders of the Pancreatic Beta Cell and Diabetes (Permanent Neonatal Diabetes and Maturity-Onset Diabetes of the Young).- ATP-Sensitive Potassium Channels in Health and Disease.- Glucokinase in Glucose Homeostasis, Diabetes Mellitus, Hypoglycemia, and as Drug Receptor.

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