Overview

Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This book provides a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated. The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact.

Full Product Details

Author:   Joseph Lorenzo (Professor of medicine in the Division of Endocrinology and Metabolism and Director of Bone Biology Research at the University of Connecticut Health Center) ,  Mark Horowitz (Professor of Orthopaedics and Rehabilitation at the Yale University School of Medicine.) ,  Yongwon Choi (Professor of Pathology and Laboratory Medicine, University of Pennsylvania; Investigator, The Leonard and Marilyn Abramson Family Cancer Research Institute, Philadelphia, PA.) ,  Hiroshi Takayanagi (Professor in the Department of Cell Signaling, Tokyo Medical and Dental University)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 19.10cm , Height: 3.00cm , Length: 23.50cm
Weight:   1.210kg
ISBN:  

9780123756701

ISBN 10:   0123756707
Pages:   470
Publication Date:   24 September 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9780128005712
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

1. Overview: The developing Field of Osteoimmunology Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi, Joseph Lorenzo 2. The Origins of Bone Cells: Osteoclasts G. David Roodman, Deborah L. Galson 3. Adaptive Immune Response David G. Hesslein, Hector L. Aguila, Mark C. Horowitz 4. The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche Henry Kronenberg, Joy Wu 5. The Signaling Pathways Regulating Osteoblast Differentiation Jane Lian, Gary Stein 6. The Signaling Pathways Regulating Osteoclast Differentiation Steven Teitelbaum, Roberta Faccio, Hiroshi Takayanagi, Yongwon Choi 7. The Effects of Immune Cells Products (Cytokines and Growth Factors) on Bone Cells Joseph Lorenzo 8. Interactions of Osteoblasts and Osteoclasts T. John Martin, Natalie A. Sims, Julian M. W. Quinn 9. The Role of the Immune System in the Development of Osteoporosis Sundeep Khosla, B. Lawrence Riggs, Ulrike I. Moedder 10. The Role of the Immune System in the Bone Loss of Inflammatory Arthritis Georg Schett, Steven Goldring 11. The Role of the Immune System in the Bone Loss of Inflammatory Bowel Disease Francisco Sylvester, Anthony T. Vella 12. The Role of the Immune System in Fracture Healing Louis Gerstenfeld, Thomas Einhorn, Brandon Steen 13. The Role of the Immune System in the Development of Chronic Infections of Bone Brendan Boyce, Edward Schwarz, Lianping Xing 14. The Role of the Immune System in Hematologic Malignancies, which Affect Bone Gregory Mundy, Claire M. Edwards, Jessica Fowler 15. The Role of the Immune System in Dental Disease Dana Graves, Rayyan A. Kayal, Thomas Oates, Gustavo Garlet

Reviews

This book provides an updated and summarized review, basic, applied, and translational, to researchers and clinicians interested in the study of the mechanisms common to both bone biology and the immune system. Consequently, this text should be considered bedtime reading, a must for professionals (bone biologists, immunologists, oncologists, dentists, rheumatologists, endocrinologists, and of course, their fellow osteoimmunol- ogists) since it is the state of the art for this exciting new discipline whose importance and relevance continues to grow exponentially in today's scientific literature. --American Journal of Human Biology, 25:135-139 (2013), November 2012 Edited by four pioneers in the field of osteoimmunology, this book contains chapters by 44 outstanding experts, spanning the breadth and depth of our current knowledge of osteoimmunology from cell and molecular biology to clinical problems. --Tatsuo Suda, Member of the Japan Academy, Associate Member, Science Council of Japan, Emerutus Professor of Showa University, Visiting Professor, Research Center for Genomic Medicine, Saitama Medical University, Japan The new textbook of osteoimmunology provides a comprehensive introduction to this recently established field that seeks to bridge two-well established disciplines. By reviewing both well-established concepts in bone biology and recent advances in our understanding of the interactions between the immune and skeletal systems, the text serves as both an excellent introduction to the field and a state of the art summary. Overall, each chapter provides concise history of work in the area, thus both immunologists and bone biologists can gain a view of how current paradigms evolved to their current states. This makes the book of particular use to trainees that have studied primarily immunology or bone biology in the past but know little about the other. Early chapters focus on specific cell types in the bone such as osteoclasts or osteoblasts and review both the cellular differentiation and function and our current knowledge regarding immune regulation of the cells. Later chapters nicely focus on specific pathologic states in the bone such as inflammatory arthritis or fracture healing and provide a comprehensive review of studies investigating the role of the immune system in these models. The field of osteoimmunology is rapidly expanding and evolving quickly, this textbook will help put all of us on the same page and help us understand how we got here. --Mary C. Nakamura M.D., Associate Professor of Medicine, UCSF, Division of Rheumatology, San Francisco, CA, USA

Edited by four pioneers in the field of osteoimmunology, this book contains chapters by 44 outstanding experts, spanning the breadth and depth of our current knowledge of osteoimmunology from cell and molecular biology to clinical problems. --Tatsuo Suda, Member of the Japan Academy, Associate Member, Science Council of Japan, Emerutus Professor of Showa University, Visiting Professor, Research Center for Genomic Medicine, Saitama Medical University, Japan The new textbook of osteoimmunology provides a comprehensive introduction to this recently established field that seeks to bridge two-well established disciplines. By reviewing both well-established concepts in bone biology and recent advances in our understanding of the interactions between the immune and skeletal systems, the text serves as both an excellent introduction to the field and a state of the art summary. Overall, each chapter provides concise history of work in the area, thus both immunologists and bone biologists can gain a view of how current paradigms evolved to their current states. This makes the book of particular use to trainees that have studied primarily immunology or bone biology in the past but know little about the other. Early chapters focus on specific cell types in the bone such as osteoclasts or osteoblasts and review both the cellular differentiation and function and our current knowledge regarding immune regulation of the cells. Later chapters nicely focus on specific pathologic states in the bone such as inflammatory arthritis or fracture healing and provide a comprehensive review of studies investigating the role of the immune system in these models. The field of osteoimmunology is rapidly expanding and evolving quickly, this textbook will help put all of us on the same page and help us understand how we got here. --Mary C. Nakamura M.D., Associate Professor of Medicine, UCSF, Division of Rheumatology, San Francisco, CA, USA

Author Information

Dr. Lorenzo is Professor of medicine in the Division of Endocrinology and Metabolism and Director of Bone Biology Research at the University of Connecticut Health Center. He is a nationally renowned expert on bone remodeling and its effect on bone health. Dr. Horowitz is Professor of Orthopaedics and Rehabilitation at the Yale University School of Medicine. His research interests include the interactions between the skeletal, immune, and hematopoietic systems as they relate to normal and pathologic bone remodeling. Dr. Choi is Professor of Pathology and Laboratory Medicine, University of Pennsylvania; Investigator, The Leonard and Marilyn Abramson Family Cancer Research Institute, Philadelphia, PA. Dr. Takayanagi is Professor in the Department of Cell Signaling, Tokyo Medical and Dental University. His group studies the mechanism of bone destruction in rheumatoid arthritis, which focuses on the regulation of osteoclasts by T cells. This interdisciplinary field, osteoimmunology, covers various research on shared mechanisms and interactions between immune and bone systems.

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