Overview

Osteocalcin is a hydroxyapatite-binding protein, which is present in bone as the most abundant non-collagenous protein. Osteocalcin is exclusively synthesised by osteoblasts. In recent years, osteocalcin, which is secreted in the general circulation from osteoblastic cells, has been shown to have several hormonal features, and it has been shown to act either as a cytokine or as a chemoattractant for osteoblasts, osteoclasts and blood monocytes and to involve in endocrine regulation of glucose homeostasis. Thus, the novel role of osteocalcin in the regulation of many functions in the living body was found in recent studies. This book will be of help in the understanding of the wide aspects of the functional role of osteocalcin and its significance in disease.

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9781619420472

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Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents.

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