Overview

Organic Synthesis: State of the Art 2011-2013 is a convenient, concise reference that summarizes the most important current developments in organic synthesis, from functional group transformations to complex natural product synthesis. The fifth volume in the esteemed State of the Art series, the book compiles two years' worth of Douglass Taber's popular weekly column Organic Chemistry Highlights. The series is an invaluable resource, leading chemists quickly and easily to the most significant developments in the field. The book is logically divided into two sections: the first section focuses on specific topics in organic synthesis, such as C-N Ring Construction and Carbon-Carbon Bond Formation. Each topic is presented using the most significant publications within those areas of research. The journal references are included in the text. The second section focuses on benchmark total syntheses, with an analysis of the strategy for each, and discussions of pivotal transformations. Synthetic organic chemistry is a complex and rapidly growing field, with additional new journals appearing almost every year. Staying abreast of recent research is a daunting undertaking. This book is an ideal tool for both practicing chemists and students, offering a rich source of information and suggesting fruitful pathways for future investigation.

Full Product Details

Author:   Douglass F. Taber (Professor of Chemistry, Professor of Chemistry, University of Delaware) ,  Tristan Lambert (Professor of Chemistry, Professor of Chemistry, Columbia University)
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Dimensions:   Width: 16.00cm , Height: 2.00cm , Length: 23.60cm
Weight:   0.499kg
ISBN:  

9780190200794

ISBN 10:   0190200790
Pages:   280
Publication Date:   08 January 2015
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

Contents Preface Organic Functional Group Interconversion and Protection 1. Functional Group Transformations http://www.organic-chemistry.org/Highlights/2012/14May.shtm May 14, 2012 2. Functional Group Interconversion http://www.organic-chemistry.org/Highlights/2012/22October. shtm October 22, 2012 3. Functional Group Interconversion http://www.organic-chemistry.org/Highlights/2013/13May.shtm May 13, 2013 4. Functional Group Interconversion http://www.organic-chemistry.org/Highlights/2013/28October. shtm October 28, 2013 5. Reduction and Oxidation http://www.organic-chemistry.org/Highlights/2012/21May.shtm May 21, 2012 6. Functional Group Oxidation and Reduction http://www.organic-chemistry.org/Highlights/2012/12November .shtm November 12, 2012 7. Functional Group Oxidation http://www.organic-chemistry.org/Highlights/2013/20May.shtm May 20, 2013 8. Functional Group Reduction http://www.organic-chemistry.org/Highlights/2013/27May.shtm May 27, 2013 9. Functional Group Protection http://www.organic-chemistry.org/Highlights/2012/28May.shtm May 28, 2012 10. Functional Group Protection http://www.organic-chemistry.org/Highlights/2012/29October. shtm October 29, 2012 11. Functional Group Protection http://www.organic-chemistry.org/Highlights/2013/10June.sht m June 12, 2013 12. Functional Group Protection http://www.organic-chemistry.org/Highlights/2013/11November .shtm November 11, 2013 Flow Methods 13. Develop of Flow Reactions September 24, 2012 14. Flow Chemistry http://www.organic-chemistry.org/Highlights/2013/25March.sh tm March 25, 2013 15. Flow Chemistry http://www.organic-chemistry.org/Highlights/2013/30Septembe r.shtm September 30, 2013 C-H Functionalization 16. C-H Functionalization: The Ono/Kato/Dairi Synthesis of Fusiocca-1,10(14)-diene-3,8?,16-triol http://www.organic-chemistry.org/Highlights/2012/19March.sh tm March 19, 2012 17. C-H Functionalization http://www.organic-chemistry.org/Highlights/2012/17Septembe r.shtm September 17, 2012 18. C-H Functionalization: The Hatakeyama Synthesis of (-)-Kaitocephalin http://www.organic-chemistry.org/Highlights/2013/28January. shtm January 28, 2013 19. C-H Functionalization http://www.organic-chemistry.org/Highlights/2013/16Septembe r.shtm September 16, 2013 20. Natural Product Synthesis by C-H Functionalization: (±)-Allokainic Acid (Wee), (-)-Cameroonan-7?-ol (Taber), (+)-Lithospermic Acid (Yu), (-)-Manabacanine (Kroutil), Streptorubin B and Metacycloprodigiosin (Challis) http://www.organic-chemistry.org/Highlights/2012/30January. shtm January 30, 2012 21. Natural Product Synthesis by C-H Functionalization: (-)-Zampanolide (Ghosh), Muraymycin D2 (Ichikawa), (+)-Sundiversifolide (Iwabuchi), (+)-Przewalskin B (Zhang/Tu), Artemisinin (Wu) http://www.organic-chemistry.org/Highlights/2012/11June.sht m June 11, 2012 Carbon-Carbon Bond Construction 22. Carbon-Carbon Bond Formation: The Bergman Synthesis of (+)-Fuligocandin B http://www.organic-chemistry.org/Highlights/2012/12March.sh tm March 12, 2012 23. C-C Bond Formation: The Petrov Synthesis of Combretastatin A-4 http://www.organic-chemistry.org/Highlights/2012/18June.sht m June 18, 2012 24. Carbon-Carbon Bond Construction: The Baran Synthesis of (+)-Chromazonarol http://www.organic-chemistry.org/Highlights/2013/11March.sh tm March 11, 2013 25. Carbon-Carbon Bond Construction http://www.organic-chemistry.org/Highlights/2013/29July.sht m July 29, 2013 26. Reactions Involving C-C Bond Cleavage http://www.organic-chemistry.org/Highlights/2013/23Septembe r.shtm September 23, 2013 Reactions of Alkenes 27. Reactions of Alkenes: The RajanBabu Synthesis of Pseudopterosin G-J Aglycone Dimethyl Ether March 26, 2012 28. Reactions of Alkenes http://www.organic-chemistry.org/Highlights/2012/10Septembe r.shtm September 10, 2012 29. Reactions of Alkenes http://www.organic-chemistry.org/Highlights/2013/18March.sh tm March 18, 2013 30. Synthesis and Reactions of Alkenes http://www.organic-chemistry.org/Highlights/2013/09Septembe r.shtm September 9, 2013 31. Advances in Alkene Metathesis: The Kobayashi Synthesis of (+)-TMC-151C http://www.organic-chemistry.org/Highlights/2012/23January. shtm January 23, 2012 Enantioselective Construction of Acyclic Stereogenic Centers 32. Enantioselective Synthesis of Alcohols and Amines: The Ichikawa Synthesis of (+)-Geranyllinaloisocyanide http://www.organic-chemistry.org/Highlights/2012/13February .shtm February 13, 2012 33. Enantioselective Synthesis of Alcohols and Amines: The Fujii/Ohno Synthesis of (+)-Lysergic Acid http://www.organic-chemistry.org/Highlights/2012/16July.sht m July 16, 2012 34. Asymmetric C-Heteroatom Bond Formation http://www.organic-chemistry.org/Highlights/2013/11February .shtm February 11, 2013 35. Construction of Single Stereocenters http://www.organic-chemistry.org/Highlights/2013/15July.sht m July 15, 2013 36. Enantioselective Construction of Alkylated Centers: The Shishido Synthesis of (+)-Helianane http://www.organic-chemistry.org/Highlights/2012/20February .shtm February 20, 2012 37. Enantioselective Synthesis of Alkylated Centers: The Fukuyama Synthesis of (-)-Histrionicotoxin http://www.organic-chemistry.org/Highlights/2012/23July.sht m July 23, 2012 38. Asymmetric C-C Bond Formation http://www.organic-chemistry.org/Highlights/2013/18February .shtm February 18, 2013 39. Arrays of Stereogenic Centers: The Davies Synthesis of Acosamine http://www.organic-chemistry.org/Highlights/2012/27February .shtm February 27, 2012 40. Construction of Alkylated Stereocenters: The Deng Synthesis of (-)-Isoacanthodoral http://www.organic-chemistry.org/Highlights/2013/08July.sht m July 8, 2013 41. Arrays of Stereogenic Centers: The Barker Synthesis of (+)-Galbelgin http://www.organic-chemistry.org/Highlights/2012/30July.sht m July 30, 2012 42. Arrays of Stereogenic Centers: The Carbery Synthesis of Mycestericin G http://www.organic-chemistry.org/Highlights/2013/25February .shtm February 25, 2013 43. Construction of Stereochemical Arrays http://www.organic-chemistry.org/Highlights/2013/22July.sht m July 22, 2013 Construction of C-O Rings 44. Stereoselective C-O Ring Construction: The Keck Synthesis of Bryostatin 1 http://www.organic-chemistry.org/Highlights/2012/09January. shtm January 9, 2012 45. C-O Ring Construction: The Georg Synthesis of Oximidine II http://www.organic-chemistry.org/Highlights/2012/09April.sh tm April 9, 2012 46. C-O Ring Construction: The Reisman Synthesis of (-)-Acetylaranotin http://www.organic-chemistry.org/Highlights/2013/14January. shtm January 14, 2013 47. C-O Ring Formation http://www.organic-chemistry.org/Highlights/2013/08April.sh tm April 8, 2013 48. C-O Ring Construction: (+)-Varitriol (Liu), (+)-Isatisine A (Panek), (+)-Herboxidiene / GEX1A (Ghosh), (-)-Englerin A (Chain), Platensimycin (Lear/Wright) http://www.organic-chemistry.org/Highlights/2012/16January. shtm January 16, 2012 49. C-O Natural Products: (-)-Hybridalactone (Fürstner), (+)- Anthecotulide (Hodgson), (-)-Kumausallene (Tang), (±)-Communiol E (Kobayashi), (-)-Exiguolide (Scheidt), Cyanolide A (Rychnovsky) http://www.organic-chemistry.org/Highlights/2012/16April.sh tm April 16, 2012 50. C-O Ring Containing Natural Products http://www.organic-chemistry.org/Highlights/2013/21January. shtm January 21, 2013 51. Total Synthesis of C-O Ring-Containing Natural Products http://www.organic-chemistry.org/Highlights/2013/15April.sh tm April 15, 2013 Construction of C-N Rings 52. C-N Ring Construction: The Harrity Synthesis of Quinolizidine (-)-217A http://www.organic-chemistry.org/Highlights/2012/23April.sh tm April 23, 2012 53. New Methods for C-N Ring Construction http://www.organic-chemistry.org/Highlights/2012/19November .shtm November 19, 2012 54. C-N Ring Construction: The Fujii/Ohno Synthesis of (-)-Quinocarcin http://www.organic-chemistry.org/Highlights/2013/22April.sh tm April 22, 2013 55. C-N Ring Construction: The Hoye Synthesis of (±)-Leuconolactam http://www.organic-chemistry.org/Highlights/2013/18November .shtm November 18, 2013 56. Alkaloid Synthesis: (-)-?-Kainic Acid (Cohen), Hyacinthacine A2 (Fox), (-)-Agelastatin A (Hamada), (+)-Luciduline (Barbe), (+)-Lunarine (Fan), (-)-Runanine (Herzon) http://www.organic-chemistry.org/Highlights/2012/30April.sh tm April 30, 2012 57. Alkaloid Synthesis: Indolizidine 207A (Shenvi), (-)-Acetylaranotin (Reisman), Flinderole A (May), Isohaouamine B (Trauner), (-)-Strychnine (MacMillan) http://www.organic-chemistry.org/Highlights/2012/26November .shtm November 26, 2012 58. Alkaloid Synthesis: (+)-Deoxoprosopinine (Krishna), Alkaloid (-)-205B (Micalizio), FR901483 (Huang), (+)-Ibophyllidine (Kwon), (-)-Lycoposerramine-S (Fukuyama), (±)-Crinine (Lautens) http://www.organic-chemistry.org/Highlights/2013/29April.sh tm April 29, 2013 59. Alkaloid Synthesis: Lycoposerramine Z (Bonjoch), Esermethole (Shishido), Goniomitine (Zhu), Grandisine (Taylor), Reserpine (Jacobsen) http://www.organic-chemistry.org/Highlights/2013/25November .shtm November 25, 2013 Substituted Benzene Derivatives 60. Substituted Benzenes: The Reddy Synthesis of Isofregenedadiol http://www.organic-chemistry.org/Highlights/2012/25June.sht m June 25, 2012 61. Substituted Benzenes: The Alvarez-Manzaneda Synthesis of (-)-Akaol A http://www.organic-chemistry.org/Highlights/2012/08October. shtm October 8, 2012 62. Substituted Benzenes: The Subba Reddy Synthesis of 7-Desmethoxyfusarentin http://www.organic-chemistry.org/Highlights/2013/17June.sht m June 17, 2013 63. Substituted Benzenes: The Gu Synthesis of Rhazinal http://www.organic-chemistry.org/Highlights/2013/14October. shtm October 14, 2013 Heteroaromatic Derivatives 64. Heteroaromatic Construction: The Sperry Synthesis of (+)-Terreusinone http://www.organic-chemistry.org/Highlights/2012/09July.sht m July 9, 2012 65. Heteroaromatic Construction: The Sato Synthesis of (-)-Herbindole http://www.organic-chemistry.org/Highlights/2012/15October. shtm October 15, 2012 66. Advances in Heterocyclic Aromatic Construction http://www.organic-chemistry.org/Highlights/2013/24June.sht m June 24, 2013 67. Synthesis of Heteroaromatics http://www.organic-chemistry.org/Highlights/2013/21October. shtm October 21, 2013 Organocatalyzed C-C Ring Construction 68. Organocatalytic Carbocyclic Construction: The You Synthesis of (-)-Mesembrine http://www.organic-chemistry.org/Highlights/2012/20August.s htm August 20, 2012 69. Organocatalyzed Carbocyclic Construction: (+)-Roseophilin (Flynn) and (+)-Galbulin (Hong) http://www.organic-chemistry.org/Highlights/2012/10December .shtm December 10, 2012 70. Organocatalytic C-C Ring Construction: Prostaglandin F2? (Aggarwal) http://www.organic-chemistry.org/Highlights/2013/12August.s htm August 12, 2013 71. Organocatalyzed C-C Ring Construction: The Hayashi Synthesis of PGE1 Me Ester http://www.organic-chemistry.org/Highlights/2013/16December .shtm December 16, 2013 Metal-Mediated C-C Ring Construction 72. Metal-Mediated Carbocyclic Construction: The Chen Synthesis of Ageliferin http://www.organic-chemistry.org/Highlights/2012/13August.s htm August 13, 2012 73. Metal-Mediated Carbocyclic Construction: The Whitby Synthesis of (+)-Mucosin http://www.organic-chemistry.org/Highlights/2012/17December .shtm December 17, 2012 74. Metal-Mediated C-C Ring Construction: (+)-Shiromool (Baran) http://www.organic-chemistry.org/Highlights/2013/19August.s htm August 19, 2013 75. Metal-Mediated Ring Construction: The Hoveyda Synthesis of (-)-Nakadomarin A http://www.organic-chemistry.org/Highlights/2013/09December .shtm December 9, 2013 Intermolecular and Intramolecular Diels-Alder Reactions 76. Intramolecular Diels-Alder Cycloaddition: 7-Isocyanoamphilecta-11(20),15-diene (Miyaoka), (-)-Scabronine G (Kanoh), Basiliolide B (Stoltz), Hirsutellone B (Uchiro), Echinopine A (Chen) http://www.organic-chemistry.org/Highlights/2012/27August.s htm August 27, 2012 77. Diels-Alder Cycloaddition: Fawcettimine (Williams), Apiosporic Acid (Helmchen), Marginatone (Abad-Somovilla), Okilactomycin (Hoye), Vinigrol (Barriault), Plakotenin (Bihlmeier/Klopper) http://www.organic-chemistry.org/Highlights/2012/24December .shtm December 24, 2012 78. Diels-Alder Cycloaddition: Defucogilvocarcin V (Bodwell), (+)-Carrisone (Danishefsky), (+)-Fusarisetin A (Theodorakis), 9?-Presilphiperfolan-1?-ol (Stoltz), 7-Isocyano-11(20), 14-epiamphilectadiene (Shenvi) http://www.organic-chemistry.org/Highlights/2013/26August.s htm August 26, 2013 79. Diels-Alder Cycloaddition: (+)-Armillarivin (Banwell), Gelsemiol (Gademann), (+)-Frullanolide (Liao), Myceliothermophin A (Uchiro), Peribysin E (Reddy), Caribenol A (Li/Yang) http://www.organic-chemistry.org/Highlights/2013/23December .shtm December 23, 2013 Stereocontrolled C-C Ring Construction 80. Chloranthalactone (Liu), Rumphellaone A (Kuwahara), Lactiflorin (Bach), Echinosporin (Hale), Harveynone (Taylor), (6,7-deoxy)-Yuanhuapin (Wender) http://www.organic-chemistry.org/Highlights/2012/31December .shtm December 31, 2012 81. Other Methods for C-C Ring Construction: The Liang Synthesis of Echinopine B http://www.organic-chemistry.org/Highlights/2013/30December .shtm December 30, 2013 Classics in Total Synthesis 82. The Reisman Synthesis of (+)-Salvileucalin B http://www.organic-chemistry.org/Highlights/2012/02January. shtm January 2, 2012 83. The Theodorakis Synthesis of (-)-Jiadifenolide http://www.organic-chemistry.org/Highlights/2012/06February .shtm February 6, 2012 84. The Yamashita/Hirama Synthesis of Cortistatin A http://www.organic-chemistry.org/Highlights/2012/05March.sh tm March 5, 2012 85. The Reisman Synthesis of (-)-Maoecrystal Z http://www.organic-chemistry.org/Highlights/2012/02April.sh tm April 2, 2012 86. The Tan/Chen/Yang Synthesis of Schindilactone A http://www.organic-chemistry.org/Highlights/2012/07May.shtm May 7, 2012 87. The Garg Synthesis of (-)-N-Methylwelwitindolinone C http://www.organic-chemistry.org/Highlights/2012/04June.sht m June 4, 2012 88. The Krische Synthesis of Bryostatin 7 http://www.organic-chemistry.org/Highlights/2012/02July.sht m July 2, 2012 89. The Fukuyama Synthesis of Gelsemoxonine http://www.organic-chemistry.org/Highlights/2012/06August.s htm August 6, 2012 90. The Carreira Synthesis of (+)-Daphmanidin E http://www.organic-chemistry.org/Highlights/2012/03Septembe r.shtm September 3, 2012 91. The Qin Synthesis of (+)-Gelsemine http://www.organic-chemistry.org/Highlights/2012/01October. shtm October 1, 2012 92. The Carreira Synthesis of Indoxamycin B http://www.organic-chemistry.org/Highlights/2012/05November .shtm November 5, 2012 93. The Nicolaou/Li Synthesis of Tubingensin A http://www.organic-chemistry.org/Highlights/2012/03December .shtm December 3, 2012 94. The Thomson Synthesis of (-)-GB17 http://www.organic-chemistry.org/Highlights/2013/07January. shtm January 7, 2013 95. The Li Synthesis of (-)-Fusarisetin A http://www.organic-chemistry.org/Highlights/2013/04February .shtm February 4, 2013 96. The Carreira Synthesis of (-)-Dendrobine http://www.organic-chemistry.org/Highlights/2013/04March.sh tm March 4, 2013 97. The Vanderwal Synthesis of Echinopine B http://www.organic-chemistry.org/Highlights/2013/01April.sh tm April 1, 2013 98. The Dixon Synthesis of Manzamine A http://www.organic-chemistry.org/Highlights/2013/06May.shtm May 6, 2013 99. The Williams Synthesis of (-)-Khayasin http://www.organic-chemistry.org/Highlights/2013/03June.sht m June 3, 2013 100. The Kuwahara Synthesis of Paspalinine http://www.organic-chemistry.org/Highlights/2013/01July.sht m July 1, 2013 101. The Ma Synthesis of Gracilamine http://www.organic-chemistry.org/Highlights/2013/05August.s htm August 5, 2013 102. The Carreira Synthesis of (±)-Gelsemoxonine http://www.organic-chemistry.org/Highlights/2013/02Septembe r.shtm September 2, 2013 103. The Evans Synthesis of (-)-Nakadomarin A http://www.organic-chemistry.org/Highlights/2013/07October. shtm October 7, 2013 104. The Procter Synthesis of (+)-Pleuromutilin http://www.organic-chemistry.org/Highlights/2013/04November .shtm November 4, 2013 105. The Harran Synthesis of (+)-Roseophilin http://www.organic-chemistry.org/Highlights/2013/02December .shtm December 2, 2013

Reviews

This book would be ideal for those needing to be on top of the literature in synthetic organic chemistry James Morey, ChemistryWorld

This book would be ideal for those needing to be on top of the literature in synthetic organic chemistry * James Morey, ChemistryWorld *

Author Information

Douglass F. Taber, who currently lives in Philadelphia, is Professor Emeritus at the University of Delaware. Professor Taber published more than 200 articles in the field of organic chemistry, and authored eight chapters and several books. His research interests include the stereoselective synthesis of natural products, new methods in synthetic organic chemistry, and computational organometallic chemistry in organic synthesis. Tristan Lambert is a Professor of Chemistry at Columbia University, where he heads a lab with the goal of advancing the field of organic synthesis by inventing transformative new reaction tools that will increase the speed, efficiency, and selectivity with which complex molecules may be constructed.

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