Overview

The use of water as a medium for promoting organic reactions has, for the most part, been non-existent, despite the fact that water has served, and continues to serve, as the solvent in which the vast majority of biochemical processes take place. Chemists have only recently come to appreciate the enormous potential that water holds for those engaged in synthetic organic and organometallic chemistry, in part because of water's unique enthalpic and entropic properties. In this volume, an international team of authors, each taking advantage of the unique properties of water for carrying out organic transformations, is brought together in order to provide a timely and concise overview of current research. The chapters focus on the practical use of water in synthetic organic chemistry, with special emphasis on Diels-Alder reactions, Claisen rearrangements, organometallic chemistry, transition-metal catalysis, oxida- tions and reductions. I am grateful to my colleagues, J. Auge, I. Beletskaya, A. Cheprakov, F. Fringuelli, J. Gajewski, P. Gamer, S. Kobayashi, A. Lubineau, D. Parker, O. Piermatti, F. Pizzo and Y. Queneau, for participating in this venture. Their knowledge and experience have been invaluable in putting this volume together.

Full Product Details

Author:   P.A. Grieco
Publisher:   Springer
Imprint:   Springer
Edition:   1998 ed.
Dimensions:   Width: 15.20cm , Height: 1.80cm , Length: 22.90cm
Weight:   0.481kg
ISBN:  

9789401060776

ISBN 10:   9401060770
Pages:   310
Publication Date:   20 April 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Diels-Alder reactions in aqueous media.- 1.1 Introduction.- 1.2 The effect of water on Diels-Alder reactivity.- 1.3 Regioselectivity and endo/exo-selectivity.- 1.4 Diastereofacial selectivity.- 1.5 Synthetic applications.- 1.6 Intramolecular cycloadditions.- References.- 2 Hetero Diels-Alder reactions.- 2.1 Introduction.- 2.2 Aza Diels-Alder reactions in aqueous media.- 2.3 Synthetic exploitation of the aqueous aza Diels-Alder reaction.- 2.4 Retro aza Diels-Alder reactions in aqueous media.- 3.- References.- 3 Claisen rearrangements in aqueous solution.- 3.1 Introduction.- 3.2 Aromatic Claisen rearrangement.- 3.3 Aliphatic Claisen rearrangement.- 3.4 Synthetic exploitation of aqueous Claisen rearrangements.- 3.5 Water as a solvent.- 3.6 Multiparameter correlation-factor analyses.- 3.7 Other developments in Claisen rearrangements in aqueous solution.- 3.8 Summary.- Acknowledgements.- References.- 4 Carbonyl additions and organometallic chemistry in water.- 4.1 Introduction.- 4.2 Barbier-type alkylation reactions.- 4.3 Conjugate 1,4-additions.- 4.4 Cross-aldol and Reformatsky-type reactions.- 4.5 Pinacol coupling reactions.- 4.6 Miscellaneous reactions.- References.- 5 Aqueous transition-metal catalysis.- 5.1 Trends in aqueous transition-metal catalysis.- 5.2 Palladium-catalyzed cross-coupling reactions.- 5.3 Heck reaction.- 5.4 Carbonylation.- 5.5 Hydroformylation.- 5.6 Hydrogenation.- 5.7 Other reactions.- References.- 6 Oxidations and reductions in water.- 6.1 Oxidations in water: introduction.- 6.2 Oxidation of carbon-hydrogen bonds.- 6.3 Oxidation of carbon-carbon double bonds.- 6.4 Other oxidations.- 6.5 Reductions in water: introduction.- 6.6 Reduction of carbon-carbon double and triple bonds.- 6.7 Reduction of carbonyl and nitro functionalities.- 6.8 Other reductions.- References.- 7 Base-catalyzed aldol- and Michael-type condensations in aqueous media.- 7.1 Introduction.- 7.2 Claisen-Schmidt reaction.- 7.3 Vinylogous aldol reaction.- 7.4 Knoevenagel reaction.- 7.5 Tollens reaction.- 7.6 Weiss-Cook reaction.- 7.7 Michael reaction.- References.- 8 Water-stable rare-earth Lewis-add catalysis in aqueous and organic solvents.- 8.1 Introduction.- 8.2 Aldol reactions.- 8.3 Allylation reactions.- 8.4 Diels-Alder reactions.- 8.5 Mannich-type reactions.- 8.6 Imino Diels-Alder reactions: synthesis of pyridine and quinoline derivatives.- 8.7 Asymmetric aza Diels-Alder reactions: synthesis of tetrahydroquinoline derivatives using a chiral lanthanide Lewis acid as catalyst.- 8.8 Micellar systems.- Acknowledgements.- References.

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