Overview

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Full Product Details

Author:   Terry P. Kenakin, PhD (Professor, Pharmacology, University of North Carolina, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   115
Dimensions:   Width: 15.20cm , Height: 3.00cm , Length: 22.90cm
Weight:   0.710kg
ISBN:  

9780123945877

ISBN 10:   0123945879
Pages:   488
Publication Date:   18 April 2013
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors Michael T. Klein, Paige N. Vinson and Colleen M. Niswender Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri GPCRs in Stem Cell Function Van A. Doze and Dianne M. Perez Application of Receptor Theory to Allosteric Modulation of Receptors David A. Hall What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors Frederick J. Ehlert Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors Jesús Giraldo Chemokine Receptor Oligomerization and Allostery Bryan Stephens and Tracy M. Handel Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

Reviews

PRAISE FOR THE SERIES Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell. --BRITISH MEDICAL JOURNAL

Praise for the series: Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell. --British Medical Journal

Author Information

Terry Kenakin PhD, Professor, Department of Pharmacology, The University of North Carolina at Chapel Hill, NC

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