Overview

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers nucleosomes, histones and chromatin and has chapters on dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, digital DNase technology, and genome-wide analysis of chromatin transition.

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Author:   Carl Wu (National Cancer Institute, Bethesda, MD) ,  C. David Allis (The Rockefeller University, New York, NY) ,  C. David Allis (The Rockefeller University, New York, NY) ,  C. David Allis (The Rockefeller University, New York, NY)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   513
Dimensions:   Width: 15.20cm , Height: 2.30cm , Length: 22.90cm
Weight:   0.690kg
ISBN:  

9780123919380

ISBN 10:   012391938
Pages:   408
Publication Date:   19 October 2012
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

18. TBC 19. Quantitative affinity measurements for chromatin binding modules and their cognate marks-- pull-downs/ITC/FP/SPR 20. TBC 21. Modified Lysine Analogs for the study of chromatin modifying enzymes and nucleosome structure 22. Map the exact polydenylation site of mRNA transcripts 23. Analysis of the mechanism of chromatin remodeling by 24. TBC 25. Dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA 26. Mechanisms of ATP-dependent chromatin remodelling revealed by high-resolution optical tweezers 27. Enzymatic analysis of the Tet proteins by TLC and mass spectrometry 28. Investigating histone modifications using quantitative mass spectrometry 29. Single-molecule studies of chromatin remodeling 30. Genome-wide mapping of nucleosomes, chromatin modifications and chromatin-modifying enzymes 31. Digital DNase technology 32. Genome-wide Analysis of Chromatin Transitions; Integration of Static and Dynamic Approaches 33. Mapping the transcription machinery on the yeast genome 34. TBC

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