Nucleic Acids in Chemistry and Biology

Author:   G Michael Blackburn (University of Sheffield, UK) ,  Martin Egli (Vanderbilt University, USA) ,  Michael J Gait (MRC Laboratory of Molecular Biology (LMB), UK) ,  Jonathan K Watts (University of Massachusetts, USA)
Publisher:   Royal Society of Chemistry
Edition:   4th edition
ISBN:  

9781788019040


Pages:   696
Publication Date:   24 June 2022
Format:   Hardback
Availability:   In Print   Availability explained
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Nucleic Acids in Chemistry and Biology


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Author:   G Michael Blackburn (University of Sheffield, UK) ,  Martin Egli (Vanderbilt University, USA) ,  Michael J Gait (MRC Laboratory of Molecular Biology (LMB), UK) ,  Jonathan K Watts (University of Massachusetts, USA)
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Edition:   4th edition
Weight:   1.529kg
ISBN:  

9781788019040


ISBN 10:   1788019040
Pages:   696
Publication Date:   24 June 2022
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Introduction and Overview; DNA and RNA Structure; Nucleosides and Nucleotides; Genes and Genomes; RNA Transcription, Processing, Modification and Translation; Noncoding RNA; Synthesis of Nucleic Acids; DNA and RNA Sequencing; Nucleic Acid Therapeutics; In Vitro Evolution and Aptamers; Covalent Modifications of Nucleic Acids and Their Repair; Reversible Small Molecule–Nucleic Acid Interactions; Protein–DNA Interactions; RNA–Protein Interactions; Physical and Structural Techniques Applied to Nucleic Acids (Online Chapter)

Reviews

It is a wonderful text that covers burgeoning, new areas (e.g. genomes and genomics) with a clarity that only true, molecular scientists tend to do. --Professor Sir Shankar Balasubramanian FRS


Author Information

Mike Blackburn has been active in chemical biology research for over 50 years, beginning with chemical synthesis of a substrate analogue for ribosomal peptide synthesis (J. Mol. Biol., 1965, 13, 617-628). He studied enzyme mechanisms with W. P. Jencks (Brandeis University, 1966-7) and launched into the use of stable analogues of phosphate esters and anhydrides for studies on nucleotides and glycolysis intermediates from the late ‘70s. This has culminated in the current use of metal fluorides to generate transition state analogues for phosphoryl transfer reactions by kinases, mutases, and isomerases. He has authored some 300 research papers, several patents, one book (“Nucleic Acids in Chemistry and Biology, 3rd Edition, RSC 2005), and is a co-author for more than 70 structures in the Protein Data Bank.

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