Overview

Since the publication of the first edition of Nuclear Hepatology almost 10 years ago, new advances have taken place, both in our understanding of liver pathophysiology and various imaging modalities. A unique feature of imaging of physiology is that it enables quanti- cation. Since liver physiology is complex, quantification has been a challenge. Many p- lications in the past have often included quantification based on home-made software not available for others. Thus, the comparison of results from one center to another becomes difficult, if not impossible. The second edition of Nuclear Hepatology addresses these issues. Sophisticated software for liver and gallbladder function has been tested and va- dated through many of our previous publications. Now that software is FDA approved and available for others through a commercial company, it is hoped that future publications of imaging of liver and gallbladder physiology would routinely include quantification. Although the function of the hepatocyte is complex, it can be broadly divided into two main categories, substrate uptake at the basolateral border and intracellular transit prior to excretion into the canaliculi. The earliest manifestation of hepatocellular injury occurs in the form of prolongation of the intracellular transit time, which occurs long before the disruption of the basolateral border with subsequent rupture and death. The liver enzymes are released into circulation after the death of the hepatocyte.

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9783642006470

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From the reviews of the second edition: This second-edition textbook on nuclear hepatology and hepatobiliary diseases is well written ! . informative, useful, handy reference book filled with detailed information, excellent illustrations, and good nuclear hepatology and nuclear hepatic images. ! I highly recommend the book to nuclear and radiology departmental and hospital libraries. It will also be a valuable addition to the nuclear physician's personal medical library, serving as an excellent reference resource for radiologists, nuclear physicians, residents, and medical students confronted with routine or unusual hepatic scan findings. (Usha A. Joseph, The Journal of Nuclear Medicine, Vol. 51 (10), October, 2010)

From the reviews of the second edition: This second-edition textbook on nuclear hepatology and hepatobiliary diseases is well written ! . informative, useful, handy reference book filled with detailed information, excellent illustrations, and good nuclear hepatology and nuclear hepatic images. ! I highly recommend the book to nuclear and radiology departmental and hospital libraries. It will also be a valuable addition to the nuclear physician's personal medical library, serving as an excellent reference resource for radiologists, nuclear physicians, residents, and medical students confronted with routine or unusual hepatic scan findings. (Usha A. Joseph, The Journal of Nuclear Medicine, Vol. 51 (10), October, 2010) Authors are among the greatest international experts in the field and with a wide and intense clinical experience. ! this book is full of useful and original information on nuclear hepatology, difficult to be found in other publications. Its main interest is in stimulating a wider diffusion of clinical indications for hepatobiliary scintigraphy in medical and surgical departments, including the emergency department, and centres for liver transplants. ! we strongly recommend this book to all nuclear physicians, from the heads of the department to residents. (Luigi Mansi and Cinzia Landolfi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, 2011)

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