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OverviewThis thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications. Full Product DetailsAuthor: Dale Jonathan WaterhousePublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2019 Weight: 0.454kg ISBN: 9783030214838ISBN 10: 3030214834 Pages: 142 Publication Date: 14 August 2020 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsReviewsAuthor InformationDale J. Waterhouse received first class B.A. and M.Sci. degrees in Natural Sciences from the University of Cambridge in 2014. He recieved a Ph.D.degree in Physics from the University of Cambridge in 2018, where his thesis work focused on development of novel endoscopic imaging techniques. This culminated in the development of two clinically translatable multispectral endoscopes, one for early detection of cancer in the oesophagus, and the other for delineation of cancer in surgical resection of pituitary adenoma. In 2018 he was awarded an EPSRC Doctoral Fellowship, allowing him to continue this work, deploying these devices in first in human clinical trials. Tab Content 6Author Website:Countries AvailableAll regions |
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