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Author:   John K. Buolamwini ,  Alex A. Adjei
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2003 ed.
Volume:   85
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   1.590kg
ISBN:  

9780896039636

ISBN 10:   0896039633
Pages:   355
Publication Date:   26 March 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Overview of Novel Anticancer Drug Targets.- Kinase Inhibitor Discovery Protocols.- Biomarker Assays for Phosphorylated MAP Kinase.- Assays for Cyclin-Dependent Kinase Inhibitors.- Identifying Inhibitors of ATM and ATR Kinase Activities.- Angiogenesis and Metastasis Protocols.- The Rat Aortic Ring Assay for In Vitro Study of Angiogenesis.- Real Time In Vivo Quantitation of Tumor Angiogenesis.- Use of Tumor-Activated Hepatic Stellate Cell as a Target for the Preclinical Testing of Anti-Angiogenic Drugs Against Hepatic Tumor Development.- Cell Motility, Adhesion, Homing, and Migration Assays in the Studies of Tyrosine Kinases.- Inflammatory Response of Tumor-Activated Hepatic Sinusoidal Endothelium as a Target for the Screening of Metastasis Chemopreventive Drugs.- Binding Assay for Selectins.- Determination of Peak Serum Levels and Immune Response to the Humanized Anti-Ganglioside Antibody-Interleukin-2 Immunocytokine.- Immunohistochemical Assays in the Clinical Setting.- Immunohistochemical Determination of EGFR-Tyrosine Kinase Inhibition in Clinical Samples.- Immunohistochemical Assays of Farnesyltransferase Inhibition in Patient Samples.- Protein Chaperoning/Degradation Protocols.- Assays for HSP90 and Inhibitors.- Assays for Proteasome Inhibition.- Protein-Protein and Protein-DNA Interactions.- The Mammalian Two-Hybrid Assay for Detection of Coactivator-Nuclear Receptor Interactions.- Preparation of DNA-Protein Complexes Suitable for Spectroscopic Analysis.- Antisense.- Antisense Oligonucleotide Inhibitors of MDM2 Oncogene Expression.- Genomics.- Pharmacogenetic Analysis of Clinically Relevant Genetic Polymorphisms.- Gene Expression Microarrays.- Methods for Isolation and Genetic Analysis of Circulating Tumor DNA in Patient Plasma.- Cell Lifespan/Longevity.- The Use of Early Sea Urchin Embryos in Anticancer Drug Testing.- In Vivo Imaging.- PET Screening of Anticancer Drugs.- Miscellaneous Protocols.- Assays for In Vitro and In Vivo Synergy.- Flow Cytometric Methods for Detection and Quantification of Apoptosis.- Assays for Neoplastic Cell Enrichment in Bone Marrow Samples.

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