Non-coding RNAs in Colorectal Cancer

Author:   Ondrej Slaby ,  George A. Calin
Publisher:   Springer International Publishing AG
Edition:   1st ed. 2016
Volume:   937
ISBN:  

9783319420578


Pages:   252
Publication Date:   09 September 2016
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Non-coding RNAs in Colorectal Cancer


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Author:   Ondrej Slaby ,  George A. Calin
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2016
Volume:   937
Dimensions:   Width: 17.80cm , Height: 1.60cm , Length: 25.40cm
Weight:   6.367kg
ISBN:  

9783319420578


ISBN 10:   3319420577
Pages:   252
Publication Date:   09 September 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction.-Part I Non-coding RNAs: biology and implications in colorectal cancer pathogenesis.-Non-coding RNAs: classification, biology and functioning.-Involvement of non-coding RNAs in hallmarks and key signaling pathways of colorectal cancer.-MicroRNAs and inflammation in colorectal cancer.- Interplay between transcription factors and microRNAs regulating epithelial-mesenchymal transitions in colorectal cancer.- Non-coding RNAs functioning in colorectal cancer stem cells.- MicroRNA Methylation in Colorectal Cancer.- Polymorphisms in non-coding RNA genes and their targets sites as risk factors of sporadic colorectal cancer.- Part II Non-coding RNAs: new class of biomarkers in colorectal cancer.- Non-coding RNAs as biomarkers for colorectal cancer screening and early detection.- Circulating non-coding RNAs as biomarkers in colorectal cancer.- Non-coding RNAs enabling prognostic stratification and prediction of therapeutic response in colorectal cancer patients.- Part III Non-coding RNAs: therapeutic targets and colorectal cancer therapeutics.- Involvement of non-coding RNAs in chemo- and radioresistance of colorectal cancer.- Non-coding RNAs: therapeutic strategies and delivery systems.- MicroRNAs as therapeutic targets and colorectal cancer therapeutics.- Summary.- Index.  

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Author Information

Ondrej Slaby obtained his PhD degree in Oncology at the Faculty of Medicine at Masaryk University in 2008, and Associate Professor of Biochemistry degree at the Faculty of Science at Masaryk University in Brno in 2012. He is currently working as scientific secretary at the Masaryk Memorial Cancer Institute in Brno and research group leader (Molecular Oncology II) at the Central European Institute of Technology (CEITEC) at Masaryk University, Brno, Czech Republic. Dr. Slaby has published extensively in the area of non-coding RNAs. He published more than sixty impacted papers and three scientific monographs. His main research interests are in the non-coding RNAs significance in solid cancer and their translational potential in diagnostics and as the therapeutic targets (Sum of the times cited: 1930, h-index 23). Dr. Slaby is a member of American Association of Cancer Research, European Association for Cancer Research, European Society for Translational Medicine, Czech Society of Oncology, Czech Society for Biochemistry and Molecular Biology (member of FEBS), and others. In 2009, dr. Slaby founded Cancer Biology Section of Czechoslovak Biological Society and in 2012 co-founded Neurooncological Section of Czech Oncological Society. In 2010 and 2012 received Award of Czech Oncological Society, in 2014 Award for Medical Research of Czech Minister of Health. He is a member of the editorial board of the World Journal of Gastroenterology, World journal of Gastrointestinal Oncology, Biomarker Research and Clinical Oncology. As a peer-reviewer collaborates with a number of respected scientific journals from the field, for instance Cancer Research, Science Reports, International Journal of Cancer, British Journal of Cancer, European Journal of Cancer, PLoS ONE, Cancer Letters, Oncology, Expert Review of Molecular Diagnostics, Biomarkers in Medicine, Current Pharmacogenomics and Personalized Medicine, Human Pathology, etc. and several international grant agencies (Associationof International Cancer Research, HRB Irelnd, WellcomeTrust, ZonMw, etc.)  and charities. 

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