Overview

Palladium-catalysed cross-coupling reactions constitute a powerful class of chemical methods for the creation of carbon-carbon and carbon-heteroatom bonds used in organic synthesis, famously recognized by the 2010 Nobel Prize awarded to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki 'for palladium-catalysed cross-couplings in organic synthesis.' These methods have become ubiquitous in academic and industrial settings alike, as applications span from industrial production of pharmaceuticals, agrochemicals, polymers, and dyes to the synthesis of complex natural products. New Trends in Cross-Coupling provides the reader with the history and basic, concepts of cross-coupling up to the state of the art in modern coupling reactions from both technology and applied perspectives. A wide breadth of topics including selecting prominent ligand types; advances in Pd-phosphine precatalysts and Pd N-heterocyclic carbene complexes; new reactions such as carboiodination; implementation of new technologies such as continuous flow and advanced metal detection methods; greener approaches to cross-coupling; as well as large-scale applications in the syntheses of pharmaceutical materials are covered. Edited by Thomas J. Colacot, an Industrial expert on cross coupling, the book contains contributions from academic and industrial world leaders in the field as well as a Forewords from Professor Barry M. Trost, Gregory C. Fu and 2010 Nobel Laureate in Chemistry Professor Ei-ichi Negishi. New Trends in Cross-Coupling serves as a reference guide for both undergraduate and graduate students as well as those who are experts in the area. '...this compilation, a Must for anyone interested in learning and using newer trends in cross-coupling.' Ei-ichi Negishi, 2010 Nobel Laureate in Chemistry 'I am very pleased to see such a book concerning cross coupling reactions published.' Professor Akira Suzuki - 2010 Nobel Laureate in Chemistry. 'this book is invaluable to anyone involved in synthesis of organic compounds for any purpose.' Professor Barry Trost, Stanford University.

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9781782620259

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Reviews

Colacot has brought together a large number of experts in the field and compiled a series of interesting and informative chapters on a variety of cross-coupling areas, with a strong emphasis on the latest developments and a move away from the most conventional topics. ...written in an accessible and clear style, are a must read for those looking for a thorough introduction to the area and some of its trade secrets. ...this book is a welcome addition to an academic's or industrialist's bookshelf. -- Igor Larrosa Chemistry World At first glance, one may question if there is need for another book on cross-coupling reactions, an area that has already been reviewed a number of times in the last decade. The answer, in short, is yes. Colacot has brought together a large number of experts in the field and compiled a series of interesting and informative chapters on a variety of cross-coupling areas, with a strong emphasis on the latest developments and a move away from the most conventional topics. This book does not replace older texts, but rather acts as an update on recent developments. New trends in cross-coupling starts with a historic timeline for the development of cross-coupling reactions, which is followed by a chapter dealing with the different classes of ligands and their unique characteristics. Chapter three goes on to deal with the various palladium pre-catalysts available, providing invaluable inside information on their usage - these include details such as photos of common catalysts at their optimum purity and also after some decomposition has occurred. Taken together, these three chapters, which are written in an accessible and clear style, are a must read for those looking for a thorough introduction to the area and some of its trade secrets. It must be noted that, although it is not obvious from the title, this book is mainly dedicated to palladium catalysis, with only a few exceptions made for other transitions metals in some chapters. Subsequent chapters provide state-of-the-art reviews on a variety of areas. I found the chapter on the use of N-heterocyclic carbenes and C-heteroatom formation reactions particularly interesting. Furthermore, the chapters on flow chemistry, green chemistry and large-scale applications of cross-couplings in the pharmaceutical industry are very welcome additions. Unfortunately, there is no chapter on decarboxylative cross-coupling reactions, which have developed significantly over the last decade, but despite this I believe this book is a welcome addition to an academic's or industrialist's bookshelf. -- Igor Larrosa Chemistry World

Author Information

Dr. Thomas John Colacot was born in Central Kerala, India. After finishing his Ph.D in Chemistry from IIT Madras with Prof. M.N.S. Rao in 1989, he moved to the University of Alabama at Birmingham for a combined teaching and post-doctoral research position in the area of Group III-V Chemistry with Prof. L. K. Krannich. In 1992, he became an Asst. Professor at Florida A & M University, while collaborating with Prof. Will Rees at Florida State University. Due to family commitments, he moved to Southern Methodist University, Dallas in 1993 to work with Professor N.S. Hosmane. Although Prof. Hosmane and Dr. Colacot did not have any previous experience in catalysis, Dr. Hosmane gave him complete freedom to explore catalysis research using mixed carborane-cyclopentadiene complexes of early transition metals for the manufacture of plastics (poly olefins). In 1995, Dr. Colacot began his career at Johnson Matthey, USA directing the homogeneous catalysis research group. With an extensive background in ligand technology obtained during his time at IIT Chennai and UAB, in conjunction with his studies in catalysis from SMU, Dr. Colacot focused his research in the area of precious metal catalysis. Through his research, Dr. Colacot and his group have generated highly active, practical palladium based cross coupling catalysts for applications in pharmaceutical, fine chemicals and academic labs. Currently, Dr. Colacot is the R & D Global Manager in Homogeneous Catalysis. He has given numerous invited and plenary lectures in many international conferences and acts as an external Ph. D thesis examiner to IITs and universities. He has contributed several publications, patents, book chapters and reviews. He is a Fellow of the Royal Society of Chemistry and has obtained a MBA from Pennsylvania State University. In 2012 Dr Colacot received the Applied Catalysis Award from the Royal Society of Chemistry and more recently, the 2015 ACS Award in Industrial Chemistry.

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