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Author:   Alan G E Wilson (Lexicon Pharmaceuticals, USA) ,  David P. Rotella ,  John Caldwell ,  Alan Wilson
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 49
Dimensions:   Width: 15.60cm , Height: 2.80cm , Length: 23.40cm
Weight:   0.822kg
ISBN:  

9781849738286

ISBN 10:   1849738289
Pages:   434
Publication Date:   20 November 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

How physicochemical properties of drugs affect their metabolism and clearance; Role of solubility, permeability and adsorption in drug discovery in development; Models for nonspecific binding and partitioning; Cytochrome P450 mediated drug metabolism; Non-cytochrome P450 enzymes and glucuronidation; Metabolite profiling; Application of humanised and other transgenic models to predict human responses to drugs; Stem cells and drug metabolism; Chemically reactive versus stable drug metabolites: Role in adverse drug reactions; Integrating metabolism and toxicity properties; Metabolomics-based approaches to determine drug metabolite profiles; Drug-drug ineteractions: regulatory and theoretical considerations, and an industrial perspective; Drug-drug interactions: Computational approaches; Induction of hepatic cytochrome P450 enzymes: Importance in drug development and toxicity; Current status and implications of transporters: QSAR analysis method to evaluate drug-drug interactions of human bile salt export pump (ABCB11/BSEP) and prediction of intrahepatic cholestasis risk; Formulation of optimizing bioavailability; Systems pharmacology modelling; Pharmacokinetic-pharmacodynamic modelling in drug development with special reference to oncology;

Reviews

In the book New Horizons in Predictive Drug Metabolism and Pharmacokinetics, Editor Alan G. E. Wilson has brought together leading experts from industry, academia, and regulatory bodies to deliver a timely overview of experimental and computational methods for the prediction of drug metabolism and pharmacokinetics. Refreshingly, the book highlights many relevant aspects that generally are not discussed in much detail in related literature. Although all chapters can be read as independent stories, studying the book from the beginning to end does have added value. The book is recommended to a broad audience of scientists interested in predictive methods for drug metabolism and pharmacokinetics. For experts, this book will be a valuable reference of the current state of research, and for postgraduate students, it will be a very good resource to obtain a global overview of the field. -- Johannes Kirchmair * ChemMedChem *

In the book New Horizons in Predictive Drug Metabolism and Pharmacokinetics, Editor Alan G. E. Wilson has brought together leading experts from industry, academia, and regulatory bodies to deliver a timely overview of experimental and computational methods for the prediction of drug metabolism and pharmacokinetics. Refreshingly, the book highlights many relevant aspects that generally are not discussed in much detail in related literature. Although all chapters can be read as independent stories, studying the book from the beginning to end does have added value. The book is recommended to a broad audience of scientists interested in predictive methods for drug metabolism and pharmacokinetics. For experts, this book will be a valuable reference of the current state of research, and for postgraduate students, it will be a very good resource to obtain a global overview of the field. -- Johannes Kirchmair ChemMedChem

Author Information

Alan G.E. Wilson is an expert in the area of drug metabolism, pharmacokinetics and toxicology. He is a Board Certified Toxicologist with over thirty years of experience working in governmental and industrial companies, conducting ADME, PK, Toxicology and risk assessments. He has over 120 peer reviewed publications, including edited books and book chapters and is a frequently invited speaker at International Symposia. He is currently Vice President of a Department of DMPK, Toxicology and Pathology.

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