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OverviewThis book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods in NMR, many of which are not widely applied but are likely to provide new opportunities for drug design. The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and interaction with targets. Particular emphasis is put on applications with unexploited potential for drug discovery and development. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity. Aimed at NMR spectroscopists and pharmaceutical scientists, this title will be invaluable at putting NMR within context in its role in drug discovery and development. This resource will be essential reading for those both new and already active in these areas. Full Product DetailsAuthor: Leoncio Garrido (Consejo Superior de Investigaciones Cientifica, Spain) , Nicolau Beckmann (Novartis, Switzerland) , William Price , John WatertonPublisher: Royal Society of Chemistry Imprint: Royal Society of Chemistry Volume: Volume 2 Dimensions: Width: 15.60cm , Height: 4.30cm , Length: 23.40cm Weight: 1.022kg ISBN: 9781849734448ISBN 10: 1849734445 Pages: 565 Publication Date: 24 July 2013 Audience: Professional and scholarly , Professional and scholarly , Professional & Vocational , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsIntroduction; Part I. Small Molecules, Proteins, Cellular Systems: New Applications of High Resolution NMR in Drug Discovery and Development; Solid-state NMR in Drug Discovery and Development; High-Resolution NMR-based Metabolic Profiling in Drug Discovery and Development; In-Cell NMR Spectroscopy to Study Protein–Drug Interactions; Part II. The Whole Organism In Vivo: Increased Sensitivity Using Cryogenic Radiofrequency Coils: Application to In Vivo Phenotyping of Mice; Recent Developments of Contrast Agents, CEST and Low Fields; Pharmacological fMRI in Drug Discovery and Development; In Vivo Proton MR Spectroscopy: Animal and Human Applications at High Fields; Hyperpolarization: Concepts, Techniques and Applications; Combined PET/MRI for Improving Quantitative Imaging; Magnetic Resonance-Based Cell Imaging Using Contrast Media and Reporter Genes; Part III. Translational drug discovery: From Biological Models to the Clinics; Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challenges; In Vivo MRI/S for the Safety Evaluation of Pharmaceuticals; Applications of MRI and MRS in Cartilage Therapeutics and Tissue Engineering; Applications of Magnetic Resonance Spectroscopy to Psychiatric Disorders; Structural Magnetic Resonance Imaging Biomarkers in Neurodegenerative Disease; Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development; Cardiovascular Magnetic Resonance; Magnetic Resonance Imaging Techniques in Cancer; Subject IndexReviewsAuthor InformationAstraZeneca, UK Tab Content 6Author Website:Countries AvailableAll regions |