Overview

Angiogenesis -- the growth of new blood vessels -- is an important natural process occurring in the body, both for health and as related to disease. Angiogenesis occurs in the healthy body to help heal wounds and to help restore blood flow to tissues after injury or insult. In females, Angiogenesis also occurs during the monthly reproductive cycle (to rebuild the uterus lining, to mature the egg during ovulation) and during pregnancy (to build the placenta, the circulation between mother and foetus). The healthy body controls Angiogenesis through a series of 'on' and 'off' switches. The main 'on' switches are known as Angiogenesis-stimulating growth factors. The main 'off' switches are known as Angiogenesis inhibitors. When angiogenic growth factors are produced in excess of angiogenesis inhibitors the balance is tipped in favour of blood vessel growth. When inhibitors are present in excess of stimulators, angiogenesis is stopped. The normal, healthy body maintains a perfect balance of angiogenesis modulators. In general, angiogenesis is 'turned off' by the production of more inhibitors than stimulators. Tumour angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Tumour angiogenesis actually starts with cancerous tumour cells releasing molecules that send signals to surrounding normal host tissue. This signalling activates certain genes in the host tissue that, in turn, cause proteins to encourage growth of new blood vessels. This new book examines its angiogenesis within the context of theory and its applications to cancer treatment.

Full Product Details

Author:   Roberta V Zubar
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   0.859kg
ISBN:  

9781594542398

ISBN 10:   1594542392
Pages:   284
Publication Date:   29 June 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Preface; The History and Development of Angiogenesis Research; The Rho GTPases and Angiogenesis; Nitric Oxide and Angiogenesis; Hemostasis and Angiogenesis; Pericytes and Angiogenesis; New Proteins from Snake Venom: Attractive Tools for Studying Angiogenesis; Calcium and Angiogenesis; The Critical Role of Inflammatory Cell Infiltration in Tumour Angiogenesis: A Target for Anti-Tumour Drug Development?; Contrast-Enhanced Dynamic Computed Tomography for the Prevalence of Tumour Angiogenesis in Lung Cancer: A Prospective Study; Angiogenesis in Gynaecological Cancers; Angiogenesis as Discriminating Aspect Between Melanoma and Uncertain Melanocytic Lesions: An Immunohistochemical Study; The Role of the Nitric Oxide Pathway in Controlling Angiogenesis in Head and Neck Cancer; Angiogenesis and Anti-Angioenesis in Neoplastic and Non-Neoplastic Diseases; Immunobiology and Regulatory Mechanisms of the Expression of Angiogenic and Angiostatic Factors in Arthritis Inflammation; Index.

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