Overview

Type 1 diabetes (T1D) is caused by the auto-immune destruction of pancreatic cells and is characterised by absolute insulin insufficiency. The disease was thought to be the prevalent type of diabetes in children and adolescents, affecting up to 0.1% of the world population. T1D is a typical complex and heterogeneous pathology, occurred in genetically predisposing subjects as a result of harmful influence of non-genetic (environmental) factors. This book explores important research in this field.

Full Product Details

Author:   Dimitry A Christiakov
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   0.636kg
ISBN:  

9781600214103

ISBN 10:   160021410
Pages:   255
Publication Date:   14 August 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Introduction; Type 1 diabetes mellitus: classification, diagnosis, clinical symptoms and management; Type 1 diabetes: epidemiology; Non-genetic risk factors in susceptibility to type 1 diabetes; Prediabetes and islet autoimmunity: islet self-antibodies and mechanisms of the breakage of peripheral self-tolerance; Evidence for the role of genetic factors in the etiology of type 1 diabetes from family and twin studies; Tools to map and identify susceptibility genes for complex diseases; Utility of animal models in genetic analysis of susceptibility to type 1 diabetes; Genetics of type 1 diabetes: a role of HLA; Genetics of type 1 diabetes: role of non-HLA genes; Shared genetic susceptibility to type 1 diabetes and other autoimmune diseases; Current approaches in the treatment of type 1 diabetes: pancreatic islet beta cell replacement; Prediction of type 1 diabetes; Index.

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