Overview

Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.

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Author:   Rudy J. Castellani (Northwestern University Feinberg School of Medicine Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Chicago, USA) ,  George Perry (Department of Biology, The University of Texas at San Antonio, University of Texas, San Antonio, TX, USA) ,  Pouya Jamshidi (Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, USA)
Publisher:   Elsevier - Health Sciences Division
Imprint:   Elsevier - Health Sciences Division
Weight:   0.450kg
ISBN:  

9780323996518

ISBN 10:   0323996515
Pages:   350
Publication Date:   30 May 2025
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

1. Historical evolution of Alzheimer’s disease and age-related pathology from Alzheimer forward 2. Introduction to the neuroanatomy of AD 3. Neurohistologic techniques and methodology 4. Plaque pathology 5. Neurofibrillary degeneration 6. Other Alzheimer disease and age-associated pathology – granulovacuolar degeneration, Hirano bodies, cerebral amyloid angiopathy 7. Consensus efforts for dementia brain interpretation at autopsy 8. Pathology of autosomal dominant Alzheimer’s disease and Down syndrome 9. Aging-related tau – primary age-related tauopathy, aging-related tau astrogliopathy, argyrophilic grain disease 10. TDP-43 in aging and Alzheimer’s disease 11. Cerebrovascular disease and cognition 12. Challenges with clinicopathological correlation 13. COVID and Alzheimer’s disease 14. Ethical considerations in the neuropathological diagnosis of AD 15. Neuropathology and the so-called amyloid cascade 16. The diagnostic process in neurodegenerative diseases, including ethical considerations

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Author Information

Dr. Rudy Castellani is a professor in the Division of Neuropathology at the Northwestern University Feinberg School of Medicine, the Program Director for the Neuropathology Fellowship Training Program, and the Neuropathology Core Director for the Northwestern University Alzheimer’s Disease Research Center at the Mesulam Center for Cognitive Neurology. He is the recipient of the 2010 Alzheimer medal from the Journal of Alzheimer’s disease. He was formerly professor and vice chair of research, at West Virginia University and the Rockefeller Neuroscience institute, and a former tenured professor and director of neuropathology at University of Maryland, Baltimore. Dr. Castellani has authored or co-authored over 330 research articles, reviews, and chapters, with a focus on neurodegenerative diseases and neurotrauma, and has been quoted in the New York Times on issues related to Alzheimer’s disease treatment.

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