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Author:   Caroline Fonta ,  László Négyessy
Publisher:   Springer
Imprint:   Springer
Edition:   1st ed. 2015
Volume:   76
Dimensions:   Width: 15.50cm , Height: 2.80cm , Length: 23.50cm
Weight:   0.974kg
ISBN:  

9789401771962

ISBN 10:   9401771960
Pages:   395
Publication Date:   07 August 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Clinical forms and animal models of hypophosphatasia.- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations.- 3 Genetically modified mice for studying TNAP function.- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis.- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex.- 6 TNAP in the retina.- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain.- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues?.- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells.- 10 Signal transduction pathways of TNAP: molecular network analyses.- 11 Vitamin B-6 Metabolism and Interactions with TNAP.- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex.- 13 TNAP and Pain Control.- 14 Neurological symptoms of Hypophosphatasia.- 15 Recombinant enzyme replacement therapy in hypophosphatasia.- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome.- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer’s disease in the focus.- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders.- Index

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