Overview

Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book (the third volume of proceedings of the Colloques Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique) is dedicated to neuronal grafting and Alzheimer's disease. The wealth of basic information presented testifies to the progress that has been achieved in intracerebral grafting and to the utility of intracerebral grafting as a tool for the understanding of brain development, adult neuronal plasticity and age-related pathology. An answer to the question, whether neuronal grafting will be useful as a therapy for Alzheimer's disease, must wait for a better understanding of the disease and the identification of animal models that can be used to test potential therapies. Meanwhile, the tool of intracerebral grafting may, in the future, be used to address the pathophysiology of Alzheimer's disease.

Full Product Details

Author:   F.H. Gage ,  A. Privat
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1989
Dimensions:   Width: 17.00cm , Height: 1.20cm , Length: 24.40cm
Weight:   0.382kg
ISBN:  

9783642483714

ISBN 10:   3642483712
Pages:   202
Publication Date:   09 April 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Neuronal Grafting and Alzheimer’s Disease: Introduction.- Nigral and Striatal Grafts to the Lesioned Neostriatum: Models of Graft Function.- Intracerebral Grafts of Dopaminergic Neurons: A Discussion of Their Functional Effects and Mechanisms of Action.- Purkinje Cell Replacement by Intracerebellar Neuronal Implants in an Animal Model of Heredodegenerative Ataxia: An Overview.- Spontaneous Remyelination and Intracerebral Grafting of Myelinating Cells in Mammals.- Synaptic Plasticity vs Pathology in Alzheimer’s Disease: Implications for Transplantation.- Host Immune Responses to Neural Transplantation: A Possible Model for Autoimmune Diseases of the Central Nervous System.- NGF in CNS: Sites of Synthesis and Effects of Novel Ways to Administer NGF on Intrinsic Cholinergic Neurons and Grafts of Cholinergic Neurons and Their Target Areas.- Short-Term Memory in Rodent Models of Ageing: Effects of Cortical Cholinergic Grafts.- Pathophysiology of the Subcortically Deafferented Hippocampus: Improvement and Deterioration of Function by Fetal Grafts.- Can Fetal Cell Grafts be Expected to Ameliorate Symptoms of Human Neurodegenerative Disorders? Evidence from Animal Models.- Age-Related Changes in Rat Hippocampal Noradrenergic Transmission: Insights from In Oculo Transplants.- Neural Grafts and Neurotransmitter Interactions in Cognitive Deficits.- Serotonin-Expressing Cells from Different Microregions of the Embryonic Rat Rhombencephalon: Behaviour in Cell Culture and in Transplants to the Adult Spinal Cord.- Two Approaches for the Reversal of Phenobarbital-Induced Behavioral Birth Defects.- Differential Neural Plasticity of Diffuse Monoaminergic and Point-to-Point Sensory Afferents as Demonstrated by Responses to Target Deprivation and Fetal Neural Transplants.- Deleteriousand “Overshoot” Effects of Intracerebral Transplants.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions