Overview

In this Special Issue Reprint in Cancers, we have collected original research articles and comprehensive review articles focusing on the disease course, disease modifiers, and treatments of tumors in patients with neurofibromatosis type 1, NF2-related schwannomatosis, and non-NF2-related schwannomatosis, aiming to achieve significant advancements in this challenging, yet fascinating, field. Neurofibromatosis type 1 (NF1), NF2-related schwannomatosis (NF2), and non-NF2-related schwannomatosis (SWN) are rare genetic disorders predisposing to the development of various tumors of the central and peripheral nervous systems. Although often benign, these neoplasms can still cause significant morbidity due to their size and/or location and are rarely amenable to surgical resection. The manuscripts collected in this Reprint aim to 1) translate pre-clinical advances into more effective treatment options for many of these tumors; and 2) to understand the natural course, disease modifiers, and biomarkers.

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9783725871988

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