Overview

Full Product Details

Author:   Jeffrey L. Cummings, MD, ScD (Director, Director, Cleveland Clinic, Lou Ruvo Centre for Brain Health, Las Vegas, Nevada) ,  Jagan A. Pillai (Director, Director, Cleveland Clinic, Lou Ruvo Centre for Brain Health, Cleveland, Ohio)
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Dimensions:   Width: 17.80cm , Height: 2.00cm , Length: 25.40cm
Weight:   1.021kg
ISBN:  

9780190233563

ISBN 10:   0190233567
Pages:   360
Publication Date:   08 December 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Table of Contents List of Contributors 1 Neurodegenerative Diseases: Evolving Unifying Principles Jeffrey Cummings and Jagan Pillai 2 Neurodegenerative Diseases as Protein Misfolding Disorders Tomohiro Nakamura and Stuart A. Lipton 3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny 4 Neuroinflammation and Neurodegenerative Diseases Taylor R. Jay, Shane M. Bemiller, Lee E. Neilson, Paul J. Cheng, and Bruce T. Lamb 5 Prion Paradigm of Human Neurodegenerative Diseases Caused by Protein Misfolding Jiri Safar 6 Neuropsychiatric Features Across Neurodegenerative Diseases Claudia R. Padilla and Mario F. Mendez 7 Brain Circuits: Pathway for NDD William Seeley 8 Fluid Biomarkers Indicative of Neurodegenerative Diseases Henrik Zetterberg and Jonathan M. Schott 9 Predementia Disorders: Neurodegenerative Diseases Predecessor States as Unifying Clinical Features Jagan Pillai 10 Genetics of Neurodegenerative Diseases: Sporadic and Autosomal Dominant Forms Lynn M. Bekris and James B. Leverenz 11 An Epigenetics Perspective on Diseases of the Central Nervous System Diego Mastroeni 12 Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases Andrew B. Knot and Ella Bossy-Wetzel 13 Cell Culture and iPS Cells and Neurodegenerative Diseases Roxana Nat and Andreas Eigentler 14 Animal Models of Neurodegenerative Diseases David Baglietto-Vargas, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla 15 Metal-Protein Attenuating Compounds in Neurodegenerative Diseases Peng Lei, Scott Ayton, and Ashley I. Bush 16 Disease modifying therapies in neurodegenerative disorders Janelle Drouin-Ouellet and Roger A. Barker 17 Immunotherapy for Neurodegenerative Disorders David Morgan 18 Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles Jeffrey Cummings and Kate Zhong 19 Conclusions on Neurodegenerative Disorders: Unifying Principles Jagan Pillai and Jeffrey Cummings Index

Reviews

Age-related neurodegeneration is among the most important, most interesting and most complex areas of science. The field is exploding with new developments, and, thankfully, therapeutic strategies. Drs. Cummings and Pillai have assembled a wonderful book exploring the common features and challenges that link the study of neurodegenerative diseases, including proteinopathy, neuroinflammation, genetics and epigenetics, biomarkers and cognitive/behavioral syndromes, with the laudable aim of facilitating cross-fertilization of ideas that may accelerate therapeutic advance. -<em>Paul</em> <em>Stephen Aisen, MD, Director, Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA</em>

Author Information

Dr. Jeffery Cummings is an internationally recognized leader in clinical trials and drug development for neurodegenerative disorders. His work has been featured in major peer-reviewed journals and his books have been influential world-wide. His work has garnered many awards. Dr. Jagan A Pillai is a cognitive neurologist at the Lou Ruvo Center for Brain Health, Cleveland Clinic. He trained as a medical doctor at the University of Kerala and obtained a PhD from Northwestern University. His training in neurology was completed at the Albert Einstein College of Medicine and at the University of California San Diego. Dr. Pillai is closely involved in helping people with memory disorders and cognitive behavioral changes from neurodegenerative diseases and in developing diagnostic and treatment strategies against neurodegenerative diseases.

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions