Overview

The latest research regarding the neurodegenerative conditions known as neuroacanthocytosis will be found in this book. Recent advances have identified the range of mutations in the causative genes. In vitro studies have identified potential protein interactions, and work on erythrocyte membranes suggests mechanisms for the generation of acanthocytes. Animal models are being generated and provide the foundation for possible therapeutic interventions.

Full Product Details

Author:   Ruth H. Walker ,  Ginger Irvine ,  M. Hallett ,  Shinji Saiki
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   1st ed. Softcover of orig. ed. 2008
Dimensions:   Width: 15.50cm , Height: 1.70cm , Length: 23.50cm
Weight:   0.498kg
ISBN:  

9783642090820

ISBN 10:   3642090826
Pages:   295
Publication Date:   15 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Forward .- Preface .- Part I: The Neuroacanthocytosis Syndromes.- Neuroacanthocytosis Syndromes - A Current Overview. Differential Diagnosis of Chorea. An Update on Hardie Neuroacanthocytosis Series. Update on McLeod Syndrome. Huntington's Disease-like 2. Neuroacanthocytosis in Japan - Review of The Literature and Cases.- Part II: Basic Research - Proteins and Erythrocytes.- The Function of Chorein. Recent studies of Kell and XK: Expression Profiles of Mouse Kell and XK mRNA. Questions of Cell Shape. Neuroacanthocytosis-related Changes In Erythrocyte Membrane Organization And Function. McLeod syndrome: A perspective from Japanese Blood Centers.- Part III: Animal Models.- A Mouse Model of Chorea-acanthocytosis. Part IV: The Structural Basis of Brain Involvement in Neuroacanthocytosis .- Functional Imaging in Neuroacanthocytosis. Volumetric Neuroimaging in Neuroacanthocytosis. Neuropathology of Chorea-acanthocytosis. The Neuropathology of McLeod Syndrome. Cerebral Involvement in McLeod Syndrome: The First Autopsy Revisited.- Part V: Clinical Aspects and Therapy.- Psychiatric morbidity in NA (title to be updated). Muscular Aspects of Chorea-acanthocytosis. Impaired Autonomic Dysfunction in Neuroacanthocytosis and Causes of Sudden Death: Analysis of a Case of Chorea-acanthocytosis with Dysautonomia. Sleep Disorders in Neuroacanthocytosis. Neurosurgery for Neuroacanthocytosis. Speech/occupational therapy in neuroacanthocytosis.- Part VI: The Way Forward.- Virtual Neuroacanthocytosis Institute - A Look Forward

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