Overview

This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics.  It reviews the historical evolution of this approach from its inception in the later 1800's to present day.   This amply referenced text covers basic discussions of spinal anatomy, embryogenesis,  neuraxial vascularity,  cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of  different intrathecal agents are explored in detail with particular reference to clinical correlates  in pain and spasticity.   Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery.   Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy.  Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics,  to be an invaluable guide to this treatment modality.

Full Product Details

Author:   Tony Yaksh ,  Salim Hayek
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2023
Weight:   2.715kg
ISBN:  

9783031395574

ISBN 10:   3031395573
Pages:   830
Publication Date:   03 January 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

History and Evolution of Intrathecal Drug Delivery.- Intraspinal Anatomy: Considerations in Intrathecal Drug Delivery.- Spinal Target Receptors in Intrathecal Drug Delivery.- Mechanisms of Action of Intrathecally Administered Agents.- Physicochemical Properties and Compounding of Intrathecally Administered Agents.- Cerebrospinal Fluid Flow Dynamics.- Uptake and Distribution of Intrathecally Administered Agents.- Animal Models of Intrathecal Drug Delivery: Clinical Correlates.- Intrathecal Drug Delivery for Pain: Medical Considerations.- Intrathecal Drug Delivery for Pain: Psychological Considerations.- Intrathecal trialing Techniques for Pain Indications.- Catheter Localization and Programming Parameters for Pain.- Maintenance and Troubleshooting of Intrathecal Therapy for Pain.- Intrathecal Agents: Choices for Pain.- Intrathecal Therapy for Cancer Pain: Best Practices.- Intrathecal Therapy for Non-Cancer Pain: Best Practices.- Managing Complications of Intrathecal Therapy for Pain.- Assessing Patients with Movement Disorders for Intrathecal Therapy.- Trialing Techniques for Spasticity.- Catheter Localization and Programming Parameters for Spasticity.- Intrathecal Agents Use for Spasticity.- Maintenance and Troubleshooting of Intrathecal Therapy for Spasticity.- Managing Complications of Intrathecal Therapy for Spasticity.- System Choices.- Implantation Techniques.- Preoperative Considerations.-   Managing Surgical Complications.- ;Special Patient Populations (Children, Anticoagulation, Other implanted devices) .- Cost Effectiveness of Intrathecal Drug Delivery.- Keys to Managing a Successful Targeted Drug Delivery Practice.- Targeted Drug Delivery: Beyond the Spinal Canal.

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Author Information

Salim M. Hayek, MD, PhD University Hospitals of Cleveland Division of Pain Medicine Department of Anesthesiology Cleveland, OH USA   Tony L. Yaksh, PhD University of California, San Diego Department of Anesthesiology and Pharmacology La Jolla, CA USA

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