Overview

Neural tube defects affect about 4000 pregnancies each year and are thus among the most common of severe birth defects. Prenatal diagnosis can now detect about 70% of neural tube defects but the tests produce many false positives, so the question is under what circumstances should they be recommended. This comprehensive volume - the collective knowledge of more than 55 experts in the field - provides lucid and authoritative discussions on this topic as well as on a wide variety of theoretical, experimental, and clinical issues.

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9780195166033

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Reviews

This is an impressive and readable synopsis of the currently available knowledge about this tragic error of early embryological development, and the sequelae which can be so far-reaching and devastating. It serves to illustrate just how much we know, and with all this at our disposal, it might suggest that we are tantalisingly close to the end of the story. Hum Genet, Vol 120

"""...my reasons for support are: 1. the topic is now a focus of intense interest 2. the proposed authors are well-qualified 3. the topics covered are appropriately broad and deep 4. Dr. Wyszynski has the overview, organizational skills and energy that he will need to get the collaborators to meet the promised deadline.""--Lewis B. Holmes, Harvard Medical School ""This book covers a very broad range, and the inclusion of some of the top people in the field, such as Drs. Godfrey Oakley, Craig McDonald and Roger Stevenson, will bring prestige to this book. Diego Wyszynski is early in his career, but he indeed has outlined an excellent group of writers to cover the topics. I believe such a book would be quite timely, and it is well organized with relatively thorough coverage of the field.""--Randi Hagerman, University of California, Davis ""Yes the proposed book is likely to make a fresh and valuable contribution...The book seems to be organized in a systematic manner...I do expect the book to be of high quality given the line up of the authors.""--Muin Khoury, Center for Disease Control and Prevention ""...offers a comprehensive, timely, and sobering review of many aspects of neural tube defects and provides a wealth of information that is communicated (for the most part) in a clear and readable fashion.""--New England Journal of Medicine ""This is an impressive and readable synopsis of the currently available knowledge about this tragic error of early embryological development, and the sequelae which can be so far-reaching and devastating.""--Human Genetics ""...my reasons for support are: 1. the topic is now a focus of intense interest 2. the proposed authors are well-qualified 3. the topics covered are appropriately broad and deep 4. Dr. Wyszynski has the overview, organizational skills and energy that he will need to get the collaborators to meet the promised deadline.""--Lewis B. Holmes, Harvard Medical School ""This book covers a very broad range, and the inclusion of some of the top people in the field, such as Drs. Godfrey Oakley, Craig McDonald and Roger Stevenson, will bring prestige to this book. Diego Wyszynski is early in his career, but he indeed has outlined an excellent gorup of writers to cover the topics. I believe such a book would be quite timely, and it is well organized with relatively thorough coverage of the field.""--Randi Hagerman, University of California, Davis ""Yes the proposed book is likely to make a fresh and valuable contribution...The book seems to be organized in a systematic manner...I do expect the book to be of high quality given the line up of the authors.""--Muin Khoury, Center for Disease Control and Prevention ""...offers a comprehensive, timely, and sobering review of many aspects of neural tube defects and provides a wealth of information that is communicated (for the most part) in a clear and readable fashion.""--New England Journal of Medicine ""This is an impressive and readable synopsis of the currently available knowledge about this tragic error of early embryological development, and the sequelae which can be so far-reaching and devastating.""--Human Genetics"

...my reasons for support are: 1. the topic is now a focus of intense interest 2. the proposed authors are well-qualified 3. the topics covered are appropriately broad and deep 4. Dr. Wyszynski has the overview, organizational skills and energy that he will need to get the collaborators to meet the promised deadline. --Lewis B. Holmes, Harvard Medical School This book covers a very broad range, and the inclusion of some of the top people in the field, such as Drs. Godfrey Oakley, Craig McDonald and Roger Stevenson, will bring prestige to this book. Diego Wyszynski is early in his career, but he indeed has outlined an excellent group of writers to cover the topics. I believe such a book would be quite timely, and it is well organized with relatively thorough coverage of the field. --Randi Hagerman, University of California, Davis Yes the proposed book is likely to make a fresh and valuable contribution...The book seems to be organized in a systematic manner...I do expect the book to be of high quality given the line up of the authors. --Muin Khoury, Center for Disease Control and Prevention ...offers a comprehensive, timely, and sobering review of many aspects of neural tube defects and provides a wealth of information that is communicated (for the most part) in a clear and readable fashion. --New England Journal of Medicine This is an impressive and readable synopsis of the currently available knowledge about this tragic error of early embryological development, and the sequelae which can be so far-reaching and devastating. --Human Genetics ...my reasons for support are: 1. the topic is now a focus of intense interest 2. the proposed authors are well-qualified 3. the topics covered are appropriately broad and deep 4. Dr. Wyszynski has the overview, organizational skills and energy that he will need to get the collaborators to meet the promised deadline. --Lewis B. Holmes, Harvard Medical School This book covers a very broad range, and the inclusion of some of the top people in the field, such as Drs. Godfrey Oakley, Craig McDonald and Roger Stevenson, will bring prestige to this book. Diego Wyszynski is early in his career, but he indeed has outlined an excellent gorup of writers to cover the topics. I believe such a book would be quite timely, and it is well organized with relatively thorough coverage of the field. --Randi Hagerman, University of California, Davis Yes the proposed book is likely to make a fresh and valuable contribution...The book seems to be organized in a systematic manner...I do expect the book to be of high quality given the line up of the authors. --Muin Khoury, Center for Disease Control and Prevention ...offers a comprehensive, timely, and sobering review of many aspects of neural tube defects and provides a wealth of information that is communicated (for the most part) in a clear and readable fashion. --New England Journal of Medicine This is an impressive and readable synopsis of the currently available knowledge about this tragic error of early embryological development, and the sequelae which can be so far-reaching and devastating. --Human Genetics

This is an impressive and readable synopsis of the currently available knowledge about this tragic error of early embryological development, and the sequelae which can be so far-reaching and devastating. It serves to illustrate just how much we know, and with all this at our disposal, it might suggest that we are tantalisingly close to the end of the story. Hum Genet, Vol 120

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