Overview

Leading experimental neurobiologists and neurosurgeons provide all the technical and practical information required to perform neural transplantation in experimental and neurological research, including a detailed consideration of the issues involved in designing and customizing such methods for specific research purposes. The authors outline the different sources of donor tissues and other materials for implantation, review the different techniques for tissue implantation into the brains of experimental animals of different species, and detail the major factors for promoting graft survival, integration, and function. All the techniques are presented in a proven format, along with alternative methods for special experimental needs. Neural Transplantation Methods constitutes the single most comprehensive sourcebook of practical information on the effective use of transplantation techniques in experimental neurobiology. Its powerful and flexible techniques will significantly aid all those now working to develop today's powerful new treatments of brain and spinal cord diseases and injuries.

Full Product Details

Author:   Stephen B. Dunnett ,  Alan A. Boulton ,  Glen B. Baker
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2000 ed.
Volume:   36
Dimensions:   Width: 15.50cm , Height: 3.10cm , Length: 23.50cm
Weight:   0.979kg
ISBN:  

9780896037939

ISBN 10:   0896037932
Pages:   556
Publication Date:   20 October 1999
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Sources of Cells for Transplantation.- Dissecting Embryonic Neural Tissues for Transplantation.- Pregraft Tissue Storage Methods for Intracerebral Transplantation.- Neural Stem Cells for Transplantation.- Immortalized Cells.- Cells from Testis for Transplantation in the CNS.- Engineered Cells and Ex Vivo Gene Transfer.- Intracerebral Gene Transfer Using Viral Vectors.- Methods of Implantation.- Basic Transplantation Methods in Rodent Brain.- Intraocular Grafting.- Neural Transplantation in the Developing CNS.- Preparation of Cell Suspensions for Transplantation.- Microtransplantation of Nigral Dopamine Neurons.- Application of Polymer-Encapsulated Cell Therapy for CNS Diseases.- Neural Transplantation in Parkinsonian Primates.- Transplanting Myelinogenic Cells into the CNS.- Labeling and Identifying Grafted Cells.- Factors in Graft Survival and Function.- Neovascularization and the Blood-Brain Barrier in Neural Transplantation.- Trophic Influences on Neural Tissue Transplants.- Neuroprotective Strategies in Neural Grafting.- Death and Survival in CNS Grafting.- Immunology.- Immunoprotection of Cell and Tissue Implants in the CNS.- Immunobiology of Neural Xenotransplantation.

Reviews

...a book with so much information is very valuable for neuroscientists. - Clinical Neurology and Neurosurgery Neural Transplantation Methods seeks to serve a particular need: to provide experimental neuroscientists with a source book of information to enable them to select and adapt transplantation techniques to their own experimental programs....Neural Transplantation Methods is a very interesting, up-to-date, and complete book on the technical and methodological issues in relation with experimental neural transplantation. It is a perfect source book of information for those who want to include the transplantation strategy in their experimental program. - Acta Neurologica Belgica

"""...a book with so much information is very valuable for neuroscientists.""- Clinical Neurology and Neurosurgery ""Neural Transplantation Methods seeks to serve a particular need: to provide experimental neuroscientists with a source book of information to enable them to select and adapt transplantation techniques to their own experimental programs....Neural Transplantation Methods is a very interesting, up-to-date, and complete book on the technical and methodological issues in relation with experimental neural transplantation. It is a perfect source book of information for those who want to include the transplantation strategy in their experimental program."" - Acta Neurologica Belgica"

...a book with so much information is very valuable for neuroscientists. - Clinical Neurology and Neurosurgery Neural Transplantation Methods seeks to serve a particular need: to provide experimental neuroscientists with a source book of information to enable them to select and adapt transplantation techniques to their own experimental programs...Neural Transplantation Methods is a very interesting, up-to-date, and complete book on the technical and methodological issues in relation with experimental neural transplantation. It is a perfect source book of information for those who want to include the transplantation strategy in their experimental program. - Acta Neurologica Belgica

a book with so much information is very valuable for neuroscientists. - Clinical Neurology and Neurosurgery Neural Transplantation Methods seeks to serve a particular need: to provide experimental neuroscientists with a source book of information to enable them to select and adapt transplantation techniques to their own experimental programs. Neural Transplantation Methods is a very interesting, up-to-date, and complete book on the technical and methodological issues in relation with experimental neural transplantation. It is a perfect source book of information for those who want to include the transplantation strategy in their experimental program. - Acta Neurologica Belgica

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